急性冠脉综合征患者血清基质金属质白酶浓度升高的临床意义  

Implications of serum matrix metalloproteinase-8 elevation in patients with acute coronary syndrome

作　　者：强华[1,2] 周朝霞[1,2] 马爱群[1,2] 程华[1,2] 周萍[1,2] 

机构地区：[1]教育部环境与疾病相关基因重点实验室 [2]西安交通大学医学院第一附属医院心内科,陕西西安710061

出　　处：《南方医科大学学报》2007年第6期831-833,共3页Journal of Southern Medical University

基　　金：教育部振兴行动计划资助项目(PZ044)~~

摘　　要：目的研究在急性冠脉综合征(ACS)患者血清中基质金属蛋白酶(MMP-8)浓度的变化及临床意义。方法临床选择80例ACS患者,43例稳定性心绞痛(SAP)患者及37例健康对照,通过ELISA方法检测血清中MMP-8的含量,观察浓度的差别和特点,同时与常见的冠心病危险因素(性别、年龄、高血压、糖尿病、血脂等)相结合,进行综合分析。结果①血清MMP-8浓度在ACS组最高,与SAP和对照组间的差异均有显著意义(P<0.01);②急性心肌梗死(AMI)组的血清MMP-8浓度值高于不稳定性心胶痛(UAP)组,有显著性差异(P<0.01),而在UAP组和SAP组之间的差异没有显著意义(P>0.05);③经Logistic回归分析,提示血清MMP-8浓度可能是预测ACS(B=4.493,P=0.000),特别是AMI(B=9.961,P=0.000)的血液指标之一。④通过相关分析和线形逐步回归发现,只有中性粒细胞可能影响血清MMP-8浓度的变化(r=0.274,P=0.001);结论①血清MMP-8浓度升高与ACS的发生,特别是和AMI的发生有着密切的关系。而且血清MMP-8浓度可能是ACS特别是AMI发生的预测指标之一。②中性粒细胞可能影响血清MMP-8浓度的变化,但它不是主要的影响因素。Objective To study the clinical significance of serum matrix metalloproteinase-8 （MMP-8） concentration variation in patients with acute coronary syndrome （ACS）. Methods Enzyme-linked immunosorbent assay （ELISA） was employed to detect serum MMP-8 content in 80 ACS patients, including 43 with acute myocardial infarction （AMI）, and 37 with unstable angina pectoris （UAP）, as well as in 43 with stable angina pectoris （SAP） cases and 37 control subjects. The risk factors for atherosclerosis pertaining to age, sex, hypertension, body mass index, smoking, family history, diabetes, hyperlipidemia, etc. were evaluated statistically in each case. Results Serum MMP-8 concentration was significantly higher in ACS group than in SAP and control groups （P〈0.01）. In ASC group, serum MMP-8 was much higher in AMI patients than in those with UAP （P〈0.01）, but similar between UAP and SAP groups （P〉0.05）. Logistic regression analysis identified serum MMP-8 concentration as the possible indicator ofACS （B=4.493, P=0.000）, and particularly AMI （B=9.961, P=0.000）. Linear correlation and linear regression analysis revealed that only neutrophils were associated with serum MMP-8 concentration variation （r=0.274, P=0.001）. Conclusions Serum MMP-8 concentration is closely associated with ACS, particularly AMI, and may serve as an indicator for predicting ACS and AMI. Neutrophils may be connected with the variation of serum MMP-8 concentration, but not as the major factor.

关 键 词：动脉粥样硬化 急性冠脉综合征 基质金属蛋白酶-8 

分 类 号：R541.4[医药卫生—心血管疾病]