康欣胶囊对颈动脉粥样硬化斑块的干预作用  

Effect of Kangxin Capsule on Carotid Atheromatous Plaque

作　　者：吴天敏[1] 杜建[1] 甘玲[2] 黄友贞[2] 许清水[2] 

机构地区：[1]福建中医学院,福建福州350108 [2]福建医科大学附属第一医院,福建福州350005

出　　处：《福建中医学院学报》2007年第3期12-15,共4页Journal of Fujian College of Traditional Chinese Medicine

摘　　要：为探讨康欣胶囊对颈动脉粥样硬化的治疗作用,将60例颈动脉粥样硬化患者,随机分为治疗组与对照组,治疗组30例给予康欣胶囊治疗;对照组30例给予阿托伐他汀钙治疗,2组患者均连续用药12周,利用高分辨力超声血管成像技术,观察颈动脉内-中膜厚度(IMT)、斑块总积分(Crouse)、斑块面积(Area)及血流参数;血液检查C-反应蛋白(CRP)、纤维蛋白原(Fib)、血脂等变化,结果显示康欣胶囊治疗后颈动脉IMT、Crouse积分、Area、血脂、hs-CRP及Fib等均较治疗前降低,差异有显著性(P<0.05或P<0.01),说明康欣胶囊具有一定程度的消减及稳定动脉粥样硬化斑块的作用。To investigate the effect of Kangxin capsule on the treatment of carotid atherosclerosis 60 CAS patients were randomly assigned into two groups, the treatment group （30 cases） with （CAS）. Kangxin capsule and the control group （30 cases） with Atorvastatin Calcium for 12 weeks. The intima-media thickness （IMT）, Crouse, area of carotid plaque （Area） and blood flow parameters of carotid artery were tested with high- resolution ultrasound, and the high-sensitive C-reactive protein （hs-CRP）, fibrinogen （Fib） and blood lipids were examined with biochemical instrument. The results showed that the levels of IMT, Crouse, Area, hs-CRP and Fib decreased significantly after treatment in the trement group （P〈0.05 or P〈0.01）. Conclusion：Kangxin capsule can reduce and stabilize the atheromatous plaque of carotid artery.

关 键 词：康欣胶囊 颈动脉 粥样硬化斑块 彩色多普勒超声 炎症介质 

分 类 号：R285.6[医药卫生—中药学]