男性老年人胰岛素抵抗指数与胰岛素分泌曲线的对照分析  

A cross-check analysis between insulin secretion curve and insulin resistance index in old mans

作　　者：刘建[1] 王运林[1] 廖文慧[1] 夏秦[1] 刘晓晴[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院老年科,武汉430030

出　　处：《临床内科杂志》2007年第6期398-399,共2页Journal of Clinical Internal Medicine

摘　　要：目的对比研究男性老年人胰岛素抵抗指数与胰岛素分泌曲线,探讨其在反映胰岛素抵抗的运用价值。方法根据体重指数将体检患者分为肥胖组与非肥胖组,测空腹血糖(FBG)、甘油三脂(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),并进行葡萄糖耐量试验(OGTT)、胰岛素释放试验(IRT);计算胰岛素抵抗指数(HOMA-IR)。结果两组间的年龄、FBG、FINS、HOMA-IR、TC等指标以及两组间OGTT血糖变化曲线无显著性差异(P>0.05);肥胖组TG、LDL-C高于非肥胖组,HDL-C低于非肥胖组;肥胖组餐后1小时、2小时的胰岛素水平明显高于非肥胖组(P<0.01)。结论高胰岛素血症首先出现在餐后,餐后高胰岛素血症比胰岛素抵抗指数更为敏感地反映胰岛素抵抗。Objective To approach the value of insulin secretion curve in reflecting insulin re-sistance by contrasting it with insulin resistance index（IRI）. Methods The old marls were divided into o-besity group and non-obesity group according to their body mass index,and the levels of FBG.TG,TC. HDL-C,LDL-C were detected. Meanwhile, oral glucose tolerance test （OGTF） and insulin releasing test （IRT） were carried out, and the insulin resistance index （HOMA-IR） was calculated. Results There weren＇t significant difference in the levels of age. FBG, FINS. hOMA-IR. TC and OGTT curves between the two groups （P〉0.05）. The levels of TG and LDL-C in obesity group exceeded that in non-obesity group （P〈0.05）. The levels of hDL-C in obesity group were lower than that in non-obesity group （P〈0.05）. The insulin levels at postprandial 1 hour and 2 hour in obesity group were higher than that of non-obesity group （P〈O.O1）. Conclusion hyperinsulinemia appear first in postprand. Postprandial hyperin-sulinemia can reflect sensitively insulin resistance than insulin resistance index.

关 键 词：胰岛素释放试验 胰岛素抵抗指数 代谢综合征 肥胖 

分 类 号：R587.1[医药卫生—内分泌]