高血压病患者的胰岛素抵抗及咪达普利对其的影响  

Insulin resistance in essential hypertension patients and effect of imidapril on it

作　　者：金婕[1] 陈静[1] 阎振成[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所高血压内分泌科,重庆400042

出　　处：《第三军医大学学报》2007年第13期1343-1344,共2页Journal of Third Military Medical University

摘　　要：目的观察咪达普利降压效果和对非肥胖高血压病(essential hypertension,EH)患者胰岛素抵抗的影响。方法对40例非肥胖EH患者进行口服葡萄糖耐量试验(oral glucosen tolerance test,OGTT)和胰岛素释放试验(insulin releasing test,IRT),测定咪达普利治疗8周前后血糖、血浆胰岛素,并与16例正常人比较。结果EH组空腹及OGTT餐后30、60、120min血浆胰岛素均显著升高(P<0.05)。咪达普利治疗8周后空腹及OGTT餐后30、60min血浆胰岛素水平下降,其中30、60min时下降显著(P<0.05)。结论EH患者存在高胰岛素血症,咪达普利治疗后降压同时可改善胰岛素抵抗。Objective To certify insuline resistance in nonobese patients with essential hypertension （EH） and observe effect of imidapril. Methods An oral glucose tolerance test （OGTY） and insulin releasing test （IRT） were performed on 40 nonobese EH patients before and after imidaprit treatment, the plasma levels of glucose and insulin were tested and compared with those of 16 normal subjects. Results The insuline level of fasting or 30, 60, 120 min after OGTT were significantly higher than those in normal group （ P 〈 0.05 ）. After 8-week imidapril treatment, the fasting insulin level decreased, and 30-minute, 60-minute insuline level after OGTT decreased more （P 〈 0.05 ）. Conclusion There is insuline resistance in EH patients and imidapril can improve it.

关 键 词：高血压 咪达普利 胰岛素抵抗 

分 类 号：R544.1[医药卫生—心血管疾病] R587.3[医药卫生—内科学]