复方苦豆子对肾性高血压大鼠心室肌Ca^(2+)含量及血浆AngⅡ的影响  

Effects of compound kudouzi on left ventricular hypertrophy,calcium in ventricular myocardium and AngⅡ in plasma of renal hypertensive rats

作　　者：周颖[1] 陈虹[1] 闫明俞[1] 

机构地区：[1]石河子大学省部共建教育部新疆特种植物药资源重点实验室,石河子832002

出　　处：《中国新药杂志》2007年第12期937-940,共4页Chinese Journal of New Drugs

基　　金：新疆生产建设兵团医药专项重点资助项目(04GG24)

摘　　要：目的:探讨复方苦豆子(CK)在逆转肾性高血压大鼠(RHR)左室肥厚的过程中,对心室肌Ca^(2+)含量及血浆血管紧张素Ⅱ(AngⅡ)水平的影响。方法:建立二肾一夹型高血压大鼠模型(2K1C-RHR),随机分为5组,即假手术组(n=10),模型组(n=11),CK高、中、低剂量组(剂量分别为33．60,16．80和8．40g·kg^(-1),n均为12)和卡托普利阳性对照组(8 mg·kg^(-1),n=10),另取10只作为假手术组。每日灌药一次,连续8周。每周测定各组动物尾动脉收缩压,在给药结束后,测定各组左室质量指数(LVMI)、左室壁厚度(LVWT)、心室肌Ca^(2+)及AngⅡ水平的影响。结果:用药1周后CK高、中剂量组血压显著下降(P＜0．05),4周后降至最低水平(P＜0．01)。CK高、中剂量组的LVMI,LVWT,心室肌Ca^(2+)含量及AngⅡ水平均显著低于模型组(P＜0．01及P＜0．05),CK高剂量与卡托普利作用相近。结论:CK对RHR的心脏重塑有一定的防治作用,其机制可能与钙拮抗作用及抑制肾素-血管紧张素系统(RAS)活性有关。Objective： To investigate the effects of compound kudouzi （CK） on left ventricular hypertrophy （LVH） , calcium in ventriclar myocardium and Ang Ⅱ in plasma of renal hypertensive rats. Methods： Two-kidney 1-clip （2K1C） renovascular hypertension was induced in male Wistar rats. Fifty- seven RHR were randomly divided into 5 groups as follows： model group（ n = 11, fed with drinking water）, high dose of CK group（ CK-H group,n = 12,33.60 g·kg^-1·d^-1） , middle dose of CK group （CK- M group, n = 12,16.80 g·kg^-1·d^-1 ） , low dose of C K group （ C K-L group, n = 12,8.40 g·kg^-1·d^-1 ） and captopril group （ Cap group, n = 10,8 mg·kg^-1·d^-1 ） , in addition, sham-operated group （ sham group, n = 10）was fed with drinking water too. All rats were treated once a day for 8 weeks. The left ventricular mass index（LVMI） , the concentrations of calcium in ventriclar myocardium and angiotension Ⅱ （Ang Ⅱ ）in plasma were measured. Results： Compared with model group, the LVMI were significantly decreased in CK-H and CK-M groups. The content of Ca^2＋ in ventriclar myocardium of CK-H and CK-M groups was markedly decreased（ P 〈 0.01, P 〈 0.05）. The concent of Ang Ⅱ in plasma of CK-H group was much lower than that in model group[ （823.60 ± 211.24） vs（ 1 345.54±＋ 99.58） pg·mL^-1, P 〈 0. 001 ]. Conclusion：Chronic use of CK can inhibit and reverse ventricular hypertropy and the effect is dose-dependent. The mechanism may be related to its calcium antagonistic properties and the decreasing activity of RAS.

关 键 词：复方苦豆子 左室肥厚 肾性高血压大鼠 钙超载 血管紧张素Ⅱ 

分 类 号：R541.3[医药卫生—心血管疾病] R972.4[医药卫生—内科学]