阿折地平的合成  

Synthesis of azelnidipine

作　　者：吴国生[1] 蒋国强[1] 吴彦涛[1] 吴仲元[1] 陈历胜[1] 

机构地区：[1]湖北省医药工业研究院有限公司,武汉430061

出　　处：《中国新药杂志》2007年第12期950-952,共3页Chinese Journal of New Drugs

摘　　要：目的:合成阿折地平。方法:以二苯基甲胺为原料,经加成、酯化、酸化、氨化、缩合等反应合成阿折地平。结果:经元素分析、Ms,IR,NMR等测试确定了化学结构,总收率21％。结论:本方法原料易得,便于工业化生产。Objective： To synthesize azenidipine. Methods： Azelnidipine was prepared from benzhydrylamine via addition, esterification, acidation, amination,condensation. Results： The total yield of azenidipine was 21% , its structure was confirmed by elemental analysis, MS, IR, NMR. Conclusion： The synthetic route for azelnidipine was convenient for raw materials availibility and industrial manufacture.

关 键 词：阿折地平 抗高血压 药物合成 

分 类 号：R972.4[医药卫生—药品] R916.41[医药卫生—药学]