脂联素与2型糖尿病的关系  

Relationship Between Adiponectin and Type 2 Diabetes

作　　者：朱翠英[1] 王青[1] 韩源[1] 黄钢[1] 

机构地区：[1]上海交通大学医学院附属仁济医院核医学科,上海200001

出　　处：《标记免疫分析与临床》2007年第2期73-75,共3页Labeled Immunoassays and Clinical Medicine

基　　金：国家自然科学基金资助项目(No.30470497)

摘　　要：测定2型糖尿病患者血清脂联素的水平,并分析它与血糖、胰岛素、血脂的相关性,从而探讨2型糖尿病患者循环血中脂联素的作用。对照组32例;2型糖尿病患者105例,其中糖尿病非肥胖组53例(BMI<25kg/m2);肥胖组52例(BMI≥25kg/m2)。用RIA检测空腹血清脂联素和胰岛素,血糖和血脂。结果表明对照组脂联素水平为9.46±0.89mg/L,非肥胖组为5.83±1.06mg/L,肥胖组为3.17±0.56mg/L,糖尿病患者脂联素明显低于对照组(P<0.05),以肥胖组低下更甚。血清脂联素与血糖、甘油三脂呈负相关,r值分别为-0.59,-0.76。脂联素可能参与了2型糖尿病的发病。脂联素测定可作为早期诊断、预防和治疗2型糖尿病的一种有效手段。In order to study the effect of plasma adiponectin on type 2 diabetes patients, the correlation between plasma adiponectin, serum glucose, insulin and plasma lipid of the patients with type 2 diabetes was analyzed. 32 subjects with normal glucose, 105 with type 2 diabetes, including 53 subjects without obesity （BMI〈25 kg/m^2） and 52 with obesity （BMI≥25kg/m^2） were involred into this study. The fasting plasma adiponectin, serum glucose, insulin and plasma lipid were measured by RIA. The results showed that the mean plasma adiponectin in normal, non-obesity and obesity group was 9.46±0. 89mg/L, 5.83±1.06mg/L and 3.17±0.56mg/L, respectively. The plasma adiponectin levels in the type 2 diabetes group were significantly lower than that in normal group （P〈0.05）, especially in obesity group. The adiponectin level was significantly correlated with serum glucose and triglyceride, r value was -0.59 and -0.76, respectively. Adiponectin may be a kind of protective factor. It takes part in the pathogenesis of type 2 diabetes, and is close correlated with insulin resistance. The plasma adiponectin might be an effective index in the early diagnosis, prevention and treatment of type 2 diabetes.

关 键 词：脂联素 2型糖尿病 放射免疫分析 

分 类 号：R587.1[医药卫生—内分泌]