咪唑斯汀对小鼠接触性变态反应模型的作用研究  

Experimental Study on the effects of Mizolastine on Murine Allergic Contact Dermatitis

作　　者：卫风蕾[1] 齐欣[1] 侯素春[1] 刘晓明[1] 

机构地区：[1]大连医科大学附属一院皮肤性病科

出　　处：《中国皮肤性病学杂志》2007年第6期340-341,344,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨咪唑斯汀对小鼠变应性接触性皮炎(ACD)的治疗作用及可能机制。方法以2,4-二硝基氟苯(DNFB)诱发的小鼠ACD为模型,设立两个不同阶段用药组观察3种剂量咪唑斯汀对小鼠耳肿胀、真皮内炎性细胞浸润、血清IL-4,IL-12和IFN-γ水平的影响。结果两个不同阶段用药组咪唑斯汀均能显著抑制ACD小鼠的耳肿胀及真皮炎症细胞浸润,并呈剂量依赖性。咪唑斯汀可降低诱发后24h和72h小鼠血清IL-12和诱发后72hIFN-γ水平。结论咪唑斯汀对小鼠ACD具有治疗作用,这种作用可能与下调致炎性细胞因子的水平有关。Objective To study the therapeutic effects of mizolastine on murine allergic contact dermatitis（ACD） and probable mechanisms. Methods The murine model of ACD induced by 2,4-dinitrnfluorobenzene （DNFB） was established. Two experimental groups were established by giving mizolastine orally in different phase and the inhibitory effect of 3 doses of the drag on mu- rine ear swelling,dermal inflammatory infiltration cell counts and the levels of serum IL-4 ,IL-12 and IFN-γwere observed. Results Murine ear swellings and the dermal inflammatory infiltration cell counts of murine were depressed with different phase of mizolastine in a dose-dependent manner. Mizolastine could down-regulate the level of serum IL-12 after ACD mice were evoked 24 h and 72 h and could down-regulate the level of serum IFN-γafter ACD mice were evoked 72h, Conclusion Mizolastine has significant therapeutic effects on murine ACD ,suggesting that mizolastine probably has effects on cytokines.

关 键 词：咪唑斯汀 ACD IL-4 IL-12 IFN-Γ 

分 类 号：R758.22[医药卫生—皮肤病学与性病学] R-322[医药卫生—临床医学]