心理应激大鼠卵巢促卵泡刺激素及黄体生成素受体的变化  

Changes of Follicle-Stimulating Hormone Receptor and Luteinizing Hormone Receptor in Rat Exposed to Psychological Stress

作　　者：柯江维[1] 王建红[2] 段荣[1] 

机构地区：[1]江西省儿童医院临床检验中心,330006 [2]广东药学院

出　　处：《天津医药》2007年第6期430-431,I0002,共3页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(项目编号:39960026)

摘　　要：目的:探讨雌性大鼠心理应激状态下,卵巢促卵泡刺激素受体(FSHR)、黄体生成素受体(LHR)的变化,进而阐明卵巢内分泌功能失调的机制。方法:采用声-光-电复合刺激作为心理应激制造大鼠卵巢内分泌功能失调模型;用免疫组化方法、图像分析仪定量分析卵巢FSHR、LHR的表达。结果:采用声-光-电复合刺激雌性大鼠后,大鼠卵巢FSHR表达上升,LHR表达下降。结论:心理应激雌性大鼠卵巢FSHR表达上升,LHR表达下降可能是卵巢内分泌功能失调的机制之一。Objective： To investigate the changes of follicle-stimulating hormone receptor （FSHR） and luteinizing hormone receptor （LHR） in ovary of female rat exposed to psychological stress, and the mechanism of ovarian dysfunction. Methods： Sound, light and electricity were combined as a psychological stressful stimulus to induce ovarian dysfunction in female rat. The levels of FSHR and LHR in ovary were measured with immunohistochemical technique and image analysis. Results： Levels of FSHR increased and LHR decreased in ovary after exposure to stressful stimuli in female rats. Conclusion： The increase of FSHR and decrease of LHR in ovary of female rat exposed to psychological stress may be one of the mechanisms underlying ovarian dysfunction.

关 键 词：应激 心理学 卵巢 受体 FSH 受体 LH 免疫组织化学 大鼠 女(雌)性 

分 类 号：R169.1[医药卫生—公共卫生与预防医学]