实验性急性肺血栓栓塞症肺动脉血管重构及意义  

The Clinical Significance of Pulmonary Vessel Remodel after Experimental Acute Pulmonary Embolism in Rabbits

作　　者：张敬霞[1] 陈永利[2] 王佩显[2] 孙根义[1] 袁志明[2] 白景文[3] 

机构地区：[1]天津市胸科医院心内科,300051 [2]天津医科大学总医院心内科 [3]天津医科大学电镜教研室

出　　处：《天津医药》2007年第6期432-433,F0003,共3页Tianjin Medical Journal

基　　金：天津市自然科学基金资助项目(项目编号:013609011)

摘　　要：目的:探讨急性肺血栓栓塞症肺动脉血管重构及其临床意义。方法:取栓塞3～24h后的急性肺血栓栓塞症动物模型的栓塞段肺动脉,同时取正常肺动脉设实验对照组,固定液固定后送检。结果:正常肺动脉内皮细胞完整,未见平滑肌细胞迁移,肌层平滑肌呈层状,多为收缩型;肺栓塞后,肺动脉内皮细胞脱落,中层平滑肌细胞向内皮迁移,可见较多的合成型平滑肌细胞,内皮下可见类凋亡平滑肌细胞。结论:急性肺栓塞后,栓塞段肺动脉局部发生血管重构,对肺动脉高压的产生可能起着一定作用。Objective： To study the pulmonary artery remodel and its clinical significance after experimental acute pulmonary embolism （APE） in rabbits. Methods： After establishing the model of acute pulmonary embolism in rabbits, the specimens were obtained in both normal and lesion pulmonary artery at 3 h, 8 h and 24 h of APE. Results： The endothelium cells were integrity in normal pulmonary artery.There was less migration of smooth muscle cell, which displayed in layers and formed systolic style. After experimental acute pulmonary embolism, a large amount of endothelial cells were denudated, lots of smooth muscle cells migrated to endothelium layer, and more of them showed synthetic style. There were some para-apoptosis ceils. Conclusion： The vessel remodel does exist in thrombo-embolism pulmonary artery after acute pulmonary embolism, which may lead to high pressure in pulmonary artery.

关 键 词：肺栓塞 急性病 血管重构 肺动脉 肌细胞 平滑肌 疾病模型 动物 兔 

分 类 号：R563.5[医药卫生—呼吸系统]