临床不合理用药分析及对策  

Analysis on irrational administrations in our hospital and methods to decrease irrational administrations

作　　者：刘爱萍[1] 魏钰茜[1] 王丽华[1] 张刘慧[1] 陶文筠[1] 孙艳[1] 王羽凝[1] 

机构地区：[1]解放军总医院医学保障部药品保障中心第一临床药局,北京100853

出　　处：《中国药物应用与监测》2007年第3期33-35,共3页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:调查分析临床不合理用药情况,寻找解决不合理用药的方法及对策。方法:采取随机抽取的方式,共抽取出院病历816份,对临床用药不合理配伍情况应用PASSTM进行统计分析。结果:816份病历中监测医嘱48306条,其中不合理医嘱6994条,占总监测医嘱的14.48%。有1031条存在中等程度的有害药物相互作用,占14.74%,严重药物相互作用30例,占0.43%。结论:临床不合理用药情况较多,部分病例中存在可能危及生命的药物联合应用,应引起临床医师的重视,联合用药易产生药剂学、药物代谢学、药效学等方面的不良相互作用,加强医嘱审查对进行药效学监护是十分必要的。Objectlve：To analyze irrational administrations in our hospital, and find the methods to improve rational administrations.Methods：816 random-sampled medical records of patients hospitalized were investigated in the respect of irrational compatibilities of medicines.Results：6994 administrations out of 48306 ones were irrational, holding 14.48%, 1031（14.74%） moderate adverse drug interactions and 30 （0.43%） severe drug interactions included.Conclusion：Doctors should give special attention to the irrational administrations, especially to which give rise to irrational compatibilities of medicines endangering patients＇ lives. Combined usage of drugs may lead to adverse drug interactions in pharmaceutics, pharmacokinetics and pharmacodynamics. It is necessary to improve the surveillance on doctors＇ introductions in order to carry on pharmacodynamics custody.

关 键 词：用药分析 不合理用药 相互作用 

分 类 号：R96[医药卫生—药理学]