石菖蒲水煎剂对吗啡依赖大鼠戒断症状的治疗作用  

THE EFFECTS OF ACROUSTATRINOWIISCHOTT DECOCTION ON WITHDRAWAL SYNDROMES IN MORPHINE DEPENDENT RATS

作　　者：刘秀平[1] 王亚龙[1] 张宏馨[1] 潘颖[1] 

机构地区：[1]河北大学医学部实验中心,保定071000

出　　处：《中国疼痛医学杂志》2007年第3期164-165,170,共3页Chinese Journal of Pain Medicine

基　　金：河北省医学科学研究重点课题(04252)

摘　　要：目的:观察石菖蒲水煎剂对吗啡依赖大鼠戒断症状的治疗作用。方法:采用连续递增皮下注射吗啡,建立吗啡依赖动物模型;给石菖蒲实验组大鼠不同剂量(2.5 g/kg、5 g/kg、7.5 g/kg)的石菖蒲水煎剂灌胃后,用纳络酮催瘾(0.5 mg/kg),观察每组大鼠戒断反应中出现的咬牙、湿狗样抖动、扭体等六种戒断症状,评价大鼠戒断反应的强度。结果:与盐水对照组比较,石菖蒲水煎剂对吗啡依赖大鼠的戒断症状均有不同程度的抑制作用,其中以5 g/kg剂量组的作用最为突出(P<0.01)。结论:石菖蒲水煎剂能明显抑制吗啡依赖大鼠的戒断症状。Objective： To investigate the effects of acroustatrinowiischott decoction on withdrawal syndromes in morphine dependent rats. Methods： A model of morphine dependent rats was established by gradually increasing the doses of morphine subcutaneous injection in rats. In acroustatrinowiischott test groups rats took three different doses acroustatrinowiischott decoction （2.5 g/kg,5 g/kg,7.5 g/kg） with IG, then rats were injected with naloxone （0.5 mg/kg）. The intensity of withdrawal syndromes was evaluated according to withdrawal syndromes such as teeth chattering, wet shakes, penile licking, weightloss, escape attempts and writhing. Results： Compared with morphine dependent control group, acroustatrinowiischott could relieve the withdrawal syndrome. The effects of 5 g/kg acroustatrinowiischott were most obvious （P 〈0.01 ）. Conclusion： Acroustatrinowiischott decoction may obviously relieve morphine withdrawal syndromes in morphine dependent rats.

关 键 词：石菖蒲 水煎剂 吗啡 戒断症状 

分 类 号：R285[医药卫生—中药学]