培哚普利对慢性心力衰竭患者血浆血管紧张素Ⅱ和纤溶酶原激活物抑制物-1水平的影响  

Effects of peidolapril on plasma angiotensin Ⅱ and plasminogen activator inhibitor-1 in patients with chronic heart failure

作　　者：陈世德[1] 陶新智[1] 伍伟锋[1] 

机构地区：[1]广西医科大学第一附属医院心内科,南宁530021

出　　处：《临床心血管病杂志》2007年第6期420-422,共3页Journal of Clinical Cardiology

基　　金：广西壮族自治区卫生厅科研基金资助(No:Z2004115)

摘　　要：目的：评价培哚普利对慢性心力衰竭（CHF）患者血浆血管紧张素Ⅱ（AngⅡ）和纤溶酶原激活物抑制物-1（PAI-1）水平的影响。方法：分别采用放射免疫法和酶联免疫吸附法测定60例CHF患者及20例健康人（正常对照组）血浆AngⅡ、PAI-1水平。60例CHF患者随机分为常规治疗组（30例）和培哚普利组（30例）。培哚普利组在常规治疗基础上加用培哚普利2～4mg,qd。治疗2周后复测血浆AngⅡ、PAI-1水平。结果：治疗前CHF患者血浆AngⅡ、PAI-1水平比正常对照组明显增高（P〈0.01）。治疗2周后,培哚普利组血浆AngⅡ、PAI-1水平比常规治疗组明显降低（P〈0.01）。结论：培哚普利不仅可抑制肾素-血管紧张素系统,而且可改善内源性纤溶功能。Objective：To evaluate the effects of peidolapril on plasma angiotensinⅡ （AngⅡ） and plasminogen activator inhibitor-1 （PAI-1） in patients with chronic heart failure （CHF）. Method： The levels of plasma Ang Ⅱ and PAI-1 were detected in 60 patients with CHF and in 20 normal controls by radio immunoassay and enzymelinked immunosorbent assay, respectively. Sixty patients with CHF were randomized to receive peidolapril 2～4 mg daily besides conventional therapy （n=30） or only conventional therapy （n=30） for two weeks. The levels of plasma Ang Ⅱ and PAI-1 were detected after treatment. Result：Compared with the normal controls, the levels of plasma AngⅡ and PAI-1 in patients with CHF were significantly increased （P〈0. 01）. Compared with the convention group, the levels of them decreased significantly in peidolapril group （P〈0. 01）. Conclusion：Peidolapril can not only inhibit renin- angiotensin system but also improve fibrinolytic function of patients with CHF.

关 键 词：心力衰竭 血管紧张素Ⅱ 纤溶酶原激活物抑制物-1 培哚普利 

分 类 号：R541.6[医药卫生—心血管疾病]