脑血肿周围继发性神经元损伤的磁共振波谱可行性研究  

Feasibility of MR spectroscopy in perihematomal secondary neuronal injury after intracerebral hemorrhage

作　　者：李澄[1] 王苇[1] 张新江[2] 殷小平[2] 何玲[1] 符长标[2] 

机构地区：[1]江苏省扬州市第一人民医院影像科,江苏扬州225001 [2]江苏省扬州市第一人民医院神经内科,江苏扬州225001

出　　处：《中国医学影像技术》2007年第6期841-844,共4页Chinese Journal of Medical Imaging Technology

基　　金：江苏省卫生厅医学科技发展基金重大招标课题(H200301)

摘　　要：目的评价1H-MRS在脑血肿周围继发性神经元损伤研究中的可行性,并对其价值进行初步探讨。方法对25例发病4周内颅内出血(ICH)患者进行MRS检查,观察血肿周围组织的MRS谱线,定量分析NAA变化和检测乳酸峰。结果88%(22/25)患者血肿周围组织获得可以进行分析的谱线。血肿周围NAA/Cr较对侧对称区域降低(11.3±8.5)%(P<0.01),NAA/Cr降低程度与血肿体积呈显著的正相关(r=0.674,P<0.05)。6例可见明确的乳酸峰。结论MRS可以应用于血肿周围损伤的研究。血肿周围NAA/Cr降低,在一定前提下反映血肿周围神经元损伤。部分患者血肿周围出现乳酸峰,但并不足以作为组织缺血的证据。Objective To verify the feasibility of MR spectroscopy （MRS） in perihematomal secondary neural after intracerebral hemorrhage （ICH） and assess its clinical value. Methods Twenty-five cases of intracerebral hemorrhage within 4 weeks after onsets were performed with MRS study, the NAA/Cr around the hemorrhage in those patients was compared with the counterparts of the symmetric area and the peaks of lactic acid were counted. Results The spectrum lines available for analysis could be obtained from 88% （22/25） of patients. The NAA/Cr around the hemorrhage decreased （[-11.3 ± 8. 5] %） in relative to the symmetric area. The degree of the decreasing was positive correlated with the hemorrhage volume （r =0. 674, P〈0.05）. Lactic acid peaks could be obviously observed in 6 cases. Conclusion MRS can be applied to study the secondary neural injury around hemorrhage. The result shows that the NAA/Cr decreases in gross samples. Under a certain premise it reflects the decrease of neurons around the hemorrhage. In some cases lactic acid peaks were observed on MR spectrum, however, it should not be a certain mark of ischemic.

关 键 词：颅内出血 磁共振波谱学 神经元 

分 类 号：R445.2[医药卫生—影像医学与核医学] R651.15[医药卫生—诊断学]