年龄对健康人大脑葡萄糖代谢率影响作用的初步研究  

Age-related differences in regional cerebral glucose metabolism in normal subjects:initial study

作　　者：李祖贵[1] 高硕[2] 蔡莉[2] 李亚军[2] 刘磊[2] 张悦[2] 冯凯琳[1] 袁飞[1] 

机构地区：[1]中国人民武装警察部队医学院附属医院放射科,天津300162 [2]天津医科大学总医院PETCT中心,天津300052

出　　处：《中国医学影像技术》2007年第6期917-920,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的采用基于体素水平的图像分析法,初步探讨年龄对健康人大脑葡萄糖代谢率的影响作用。方法对40例健康人进行静息状态下的18F-FDGPET脑显像。根据年龄将受试者分为29例年轻组和11例老年组,对两组之间的18F-FDGPET数据进行基于体素水平的图像分析。结果老年组双侧额叶、颞叶、顶叶及前扣带回等部位葡萄糖代谢较年轻组减低;年轻组双侧额叶内侧部、扣带回、楔前叶及小脑半球等部位葡萄糖代谢较老年组减低。结论不同年龄组健康人的大脑葡萄糖代谢率不同,随着年龄增加健康人大脑葡萄糖代谢率减低的脑区主要包括双侧额叶、扣带回及颞叶等部位。Objective To investigate the age-related changes in regional cerebral glucose metabolism in normal subjects un der the resting state using a voxel-based method. Methods We studied 40 healthy volunteers （29 young group, 51.4± 6.4 years, and 11 old group, 72.24±3.9 years）. To evaluate the regional cerebral metabolic rate of glucose （rCMRglc）, ^18F- FDG PET imaging was performed in all subjects. All individual data was transformed to standard brain space, the young and old groups were compared using statistical parametric mapping. Results The regional cerebral glucose metabolism was found to be different between the young and old group. The young group had significantly higher glucose metabolism in the inferior frontal and superior temporal cortex bilaterally, and the left medial frontal cortex, left precuneus, left angular gyrus and right anterior cingulate cortex ipsilaterally. However, significant positive correlations of age with regional cerebral glu cose metabolism were observed in bilateral medial frontal cortex, cingulate cortex and the cerebellum structures. Conclusion We found that there were obvious age-related differences in regional cerebral glucose metabolism. Using the voxel-based analytical method to evaluate ^18 F-FDG PET images of degenerative dementia is valuable for studying regional cerebral glucose metabolism in normal subjects.

关 键 词：葡萄糖代谢率 统计参数图 氟代-脱氧葡萄糖 体层摄影术 发射型计算机 

分 类 号：R817.4[医药卫生—影像医学与核医学]