江苏省部分地区儿童抗b型流行性感冒嗜血杆菌多糖抗体水平调查  

Natural Immunity Antibody Level to Haemophilus Influenzae Type b Polysaccharide in Jiangsu Province

作　　者：吴涛[1] 陶红[2] 李红[3] 汪华[2] 

机构地区：[1]南京医科大学公共卫生学院,江苏南京210029 [2]江苏省疾病预防控制中心,南京210009 [3]中国药品生物制品检定所,北京100050

出　　处：《中国计划免疫》2007年第3期267-269,共3页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解江苏省部分地区儿童抗b型流行性感冒(流感)嗜血杆菌荚膜多糖(Hib-PRP)自然抗体水平。方法用酶联免疫吸附试验检测1 429份不同年龄组健康儿童血清的抗Hib多糖抗体。结果抗Hib多糖抗体总阳性率为61.86%,抗体水平随年龄的变化是:新生儿脐带血抗体水平高,1～3月龄下降,4～6月龄降至最低,随后抗体水平随年龄的增长而逐渐增高。结论江苏省部分地区儿童抗Hib多糖抗体水平较高,6月龄抗体水平最低,为Hib疾病的高危人群。Objective To investigate the natural antibody level to polysaccharide in Chuzhou, Danyang＇ and Binhai. Methods The natural antibody level to Haemophilus influenzae type b polysaccharide was measured with enzyme linked immunosorbent assay 1429 serum samples from core blood, infant and children were collected from different areas. Results The positive rate of antibody was 61.86%. Different age groups showed that the antibody of neonates was high,it declined to the lowest at 6 months,and those over 6 months the antibody level was increasing with the age. Also the antibody levels were different in three regions of different age groups. Conclusion General immunity against Hib disease were not low in Jiangsu Province. Children aged 6 months with lowest natural antibody level to PRP were the population under high-risk.

关 键 词：B型流行性感冒嗜血杆菌 多糖抗体 酶联免疫吸附试验 

分 类 号：R378.141[医药卫生—病原生物学]