文拉法辛对抑郁症患者睡眠的影响  

Effects of Venlafaxine on the sleep of depressed patients

作　　者：邓先华[1] 孙学礼[1] 张波[1] 舒放[1] 唐娴[1] 刘协和[1] 

机构地区：[1]四川大学华西医院心理卫生中心,四川成都610041

出　　处：《华西药学杂志》2007年第3期351-353,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家十五攻关课题资助项目(项目编号:2004DA7210A21)

摘　　要：目的探讨文拉法辛对抑郁症患者多导睡眠图及主观睡眠质量的影响。方法对20名抑郁症患者及30名正常对照者进行多导睡眠图检测,并应用匹兹堡睡眠质量指数(PSQI)和汉密尔顿抑郁量表(HAMD)睡眠障碍因子分评定抑郁症患者的主观睡眠质量。比较治疗前后多导睡眠图指标和主观睡眠质量的变化。结果与对照组比较,病例组显示多导睡眠图指标异常。病例组经过文拉法辛治疗后与治疗前比较,多导睡眠图显示觉醒次数和觉睡比增加、睡眠效率降低、睡眠阶段S1百分比增加、快眼动(REM)睡眠时间及百分比减少、REM睡眠潜伏期延长、REM活动度及强度降低,但PSQI和HAMD睡眠障碍因子分均明显降低。结论文拉法辛能抑制抑郁症患者的REM睡眠,并加重睡眠维持障碍,导致浅睡眠增加,但能够明显改善患者的主观睡眠质量。OBJECTIVE To study the effects of Venlafaxine on polysomnogram and subjective sleep quality of depressed patients. METHODS Polysomnogram assessments were conducted in 20 depressed subjects and 30 normal controls, and the patient group, subjective sleep quality was evaluated by using the Pittsburgh Sleep Quality Index （ PSQI）, Hamilton Depression Scale（HAMD） and total score of sleep disturbance factor. Then the polysomnographic parameters and subjective sleep quality were compared with those before treatment. RESULTS Compared with the control group, the patient group showed a number of abnormal polysomnographic parameters. After treatment with Venlafaxine in patient group, compared with baseline data ,they showed increased number of awakening and awakening - asleeping ratio, decreased sleep efficiency, increased percentage of Stage 1 sleep, reduced REM sleep time and percentage, prolonged REM sleep latency, decreased REM activity and intensity. However, both PSQI total score and HAMD sleep disturbance factor total score decreased obviously. CONCLUSION Venlafaxine can inhibit REM sleep in depressed patients, aggravate their sleep maintenance disorder and result in increase of light sleep, but it can significantly improve their subjective sleep quality.

关 键 词：抑郁症 文拉法辛 多导睡眠描记术 睡眠 

分 类 号：R969[医药卫生—药理学]