BQ123抑制低温诱发肺动脉高压肉鸡的肺小动脉肌型化  

BQ123 Inhibited The Muscularization of Nonmuscular Pulmonary Artery Induced by Low Ambient Temperature in Broiler

作　　者：范春艳[1] 宋金祥[1] 乔健[2] 刘文菊[2] 王慧煜[2] 王建琳[2] 邹素梅[2] 

机构地区：[1]河北工程大学农学院,河北邯郸056021 [2]中国农业大学动物医学院,北京100094

出　　处：《中国家禽》2007年第2期18-21,共4页China Poultry

基　　金：国家自然基金项目(30070567;30371063)

摘　　要：本试验用高选择性内皮素A受体拮抗剂BQ123处理低温肉鸡的方法,通过动态观察肺动脉压及肌型、部分肌型及非肌型肺小动脉数量的变化,探讨内源性内皮素在肺血管重塑中的作用。结果显示:30日龄时,低温组平均肺动脉压极显著高于常温组、低BQ123组及高BQ123组(P<0.01);低温组肌型及部分肌型肺小动脉的占位比均极显著高于常温组、低BQ123组及高BQ123组(P<0.01);低温组非肌型肺小动脉占位比极显著低于常温组、低BQ123组和高BQ123组(P<0.01),高BQ123组显著高于低BQ123组(P<0.05)。结果表明,BQ123可明显抑制低温肉鸡肺动脉高压和非肌型肺小动脉的肌型化的发生发展,因此认为内源性ET在低温诱发肺动脉高压肉鸡肺血管重塑的发生发展过程中起重要作用。BQ123,a selective endothelin（ET）A-receptor antagonist,was used to treat broilers. This study investigated the effects of ET on the museularization of nonmuseular pulmonary artery in pulmonary hypertension（PH）induced by low ambient temperature. The results showed as follows：the mPAP of low temperature group （LT） was obviously highly than that of control group（CG）, low BQ123 group（LBQ123）and high BQ123 group（HBQ123）（P〈0.01）at 30 days age;MA% and PMA% of LT were obviously greater than that of CG,HBQ123 and LBQ123（P〈0.01）at 30 days age;NMA% of LT were obviously smaller than that of CG,LBQ123 and HBQ123 （P〈0.01） at 30 days age, It was concluded that BQ123 could significantly inhibit the museularization of nonmuseular pulmonary artery induced by low ambient temperature in broilers, Therefore ET played an important role in the development of the museularization of nonmuseular pulmonary artery of PH broilers induced by low ambient temperature.

关 键 词：肉鸡 肺动脉高压 肺血管重塑 BQ123 内皮素 

分 类 号：S858.31[农业科学—临床兽医学]