盐酸埃他卡林对自发性高血压大鼠血浆生化指标及炎症相关因子的影响  

The Influence to the inflammation associated factor and plasma biochemical index on the Spontaneously Hypertensive Rats by Iptakalim Hydrochloride

作　　者：曾伏虎[1] 杨胜万[1] 刘国树[1] 汪海[1] 

机构地区：[1]解放军总医院心内科,100853

出　　处：《中国分子心脏病学杂志》2007年第3期143-145,共3页Molecular Cardiology of China

摘　　要：目的观察盐酸埃他卡林(Ipt)对自发性高血压大鼠血浆生化指标及炎症相关因子的影响。方法SHR大鼠在2月龄进入实验,体重200～250g,雌雄不限,随机分为6组:SHR对照组5只,WKY对照组5只,Ipt 3个剂量1、3、9mg·kg^(-1)·d^(-1)治疗组各6只,苯那普利(Ben)6mg·kg^(-1)·d^(-1)治疗组6只。灌胃给药每天1次,8wk后处死动物,检测血浆Glu,Tcho,TG,LDL-c,HDL-c, BUN,Cr,UA,Ins,hs-CRP,IL-6,TNF-α等指标。结果SHR大鼠对照组较WKY大鼠对照组,血浆BUN,Cr,UA显著增高(P＜0．05),血糖、血脂无显著差异(P＞0．05),经Ipt 1、3、9mg·kg^(-1)·d^(-1)及Ben 6mg·kg^(-1)·d^(-1)治疗后,血浆BUN,Cr,UA降至正常;SHR大鼠与WKY大鼠对照组比较,血浆Ins、hs-CRP、TNF-α、IL-6显著增高,Ipt 3、9mg·kg^(-1)·d^(-1)剂量治疗后,较SHR对照组大鼠均显著降低(P＜0．05),1mg·kg^(-1)·d^(-1)剂量及Ben治疗后,无明显改变(P＞0．05)。结论盐酸埃他卡林及苯那普利均能有效地改善肾功能,盐酸埃他卡林3、9mg·kg^(-1)·d^(-1)剂量治疗后能降低血浆Ins、TNF-α、IL-6、hs-CRP等炎症相关因子。Objective It is to observe the Influence of inflammation associated factor and plasma biochemical index on the Spontaneously Hypertensive Rats by Iptakalim Hydrochloride. Method SHR entered the experiment at 2 month old, weighed at 200 - 250gram. They were randomly divided into 6 groups ： SHR control group 5 animals;WKY control group 5 ;3 Ipt treating groups（ at 1.3.9 mg ·kg^-1·d^-1 dosages） each have 6 animals ; Benapril （ 6 mg ·kg^-1·d^-1 ） treating groups （ 6 animals）. The medicine were given through stomach infusion every day. 8 weeks later, rats were killed for plasma exam. Glu,Tcho, TG, LDL- c, HDL-c, BUN,Cr, UA, Ins, hs-CRP, IL-6, TNF-α were tested for each rat. Results Compare with WKY, the BUN,Cr,UA of SHR control increased markedly（P 〈0.05） ;but the Glu and the Tcho,TG, LDL- c, HDL-c has no difference（P 〉0.05）. After treating with Ipt 1,3.9 mg ·kg^-1·d^-1 and Ben 6 mg ·kg^-1·d^-1 ,the BUN,Cr,UA in the SHR plasma were decreased to normal. The Ins,hs-CRP.TNF-α.IL-6 in SHR control were increase markedly （P 〈 0.05 ） than WKY control, and after 8 weeks treatment with Ipt at the dosages of 3.9 mg ·kg^-1·d^-1 ,these index could come back to normal, but Ipt 1 mg·kg^-1·d^-1 and Ben 6 mg·kg^-1·d^-1 had no same effect （ P 〉 0.05 ）. Conclusion Ipt and Ben can improve the function of kidney effectively,and the Ipt at the dose of 3,9 mg ·kg^-1·d^-1 can decrease the higher plasma Ins,TNF-α,IL-6,hs-CRP in SHR control to the normal lever.

关 键 词：盐酸埃他卡林 自发性高血压大鼠 炎症相关因子 

分 类 号：R544.1[医药卫生—心血管疾病]