血脂清胶囊对实验性脂质代谢紊乱大鼠血脂的影响  

Effects of Xuezhiqing Capsule on Blood Lipid of Rats with Experimental Disorder of Lipid Metabolism

作　　者：顾勤[1] 胡小鹰[2] 孙小玉[2] 夏卫军[1] 汪红[1] 

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210029 [2]南京中医药大学中医药研究院,江苏南京210029

出　　处：《时珍国医国药》2007年第3期515-516,共2页Lishizhen Medicine and Materia Medica Research

基　　金：江苏省教育厅自然科学基金(No.98KJB360004)

摘　　要：目的观察血脂清胶囊对高脂大鼠脂质代谢的影响。方法采用高脂饲料建立高脂血症大鼠模型,给予血脂清治疗,检测血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、超氧化物歧化酶(SOD)、丙二醛(MDA)、血清游离脂肪酸(NEFA)等指标。结果血脂清胶囊能显著降低高血症大鼠血清TC,TG,LDL-C,MDA水平,降低肝脏TC,TG及全血比黏度(ηb),升高血清SOD水平,减轻肝细胞脂变程度,与模型组相比具有显著性差异(P<0.05,P<0.01)。结论血脂清胶囊对高脂血症大鼠的血脂代谢紊乱具有良好的调节作用,而且能提高高脂血症大鼠抗氧化能力。Objective To observe the effects of Xuezhiqing Capsule on the lipid metabolism in the hyperlipidemia rats. Methods Feeding with high fat feedstuff to establish the hyperlipidmia model in rats and detecting the various indexes of lipid including the total cholesterol （ TC）, triglyceride （TG） ,low density lipoprotein cholesterol（ LDL-C）, high density lipoprotein cholesterol （ HDL- C） ,superoxide dismutase（SOD）, malondialenhyde （MDA） and so on. Results Xuezhiqing Capsule could obviously decrease the levels of TC ,TG,LDL-C, MDA,＇qb in rat serum,TC and TG in liver, increase the level of SOD and alleviate the lipid change of livercell ,showing obvious difference from the model group（ P 〈0.05 or P 〈 0.01 ）. Conclusion Xuezhiqing Capsule not only prossesses obvious effect of regulating the disorder of lipid circulation in hyperlipidemia rats,but also can increase the antioxidation against lipid peroxidation.

关 键 词：高脂血症 血脂清胶囊 脂质过氧化 

分 类 号：R285.5[医药卫生—中药学]