五磨饮子促进大鼠胃液分泌及保护胃黏膜等作用的实验研究  

Experimental Study of Wumo Decoction on Improving Gastric Juice Excretion and Protecting Gastric Mucosa in Rats

作　　者：尚德师[1] 李乐军[1] 邵祖燕[2] 

机构地区：[1]江苏省连云港市中医医院,222004 [2]天津中医药大学第二附属医院,天津300193

出　　处：《时珍国医国药》2007年第3期588-589,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的观察五磨饮子对大鼠胃液分泌、胃黏膜保护等作用。方法采用Shay方法造成大鼠胃溃疡模型,观察灌服五磨饮子、思密达、生理盐水后大鼠胃液分泌总量、胃内总酸度、胃蛋白酶活性、损伤指数、溃疡发生率等指标的变化。结果五磨饮子与思密达均可明显促进胃液分泌(P<0.01),五磨饮子可明显提高胃酸分泌、明显抑制胃蛋白酶活性(P<0.01),思密达不影响胃酸分泌、不影响胃蛋白酶活性(P>0.05),五磨饮子、思密达均可降低Shay大鼠的损伤发生率,均有保护胃黏膜作用,五磨饮子保护胃黏膜作用较思密达为优。结论五磨饮子具有促进大鼠胃液分泌,抑制胃蛋白酶活性,保护胃黏膜等作用。作用机理可能与兴奋迷走神经、增加胃黏膜血流量有关。Objective To study the effects of Wumo Decoction on gastric juice excretion and gastric mucosa. Methods The gastric ulcer was induced by Skay method and total quantity of gastric juice excretion, total acidity in Protectctgon stomach,activity of pepsin,injury index,incidence rate of ulcer in rats were observed after administering Wumo Decoction, Smecta,Sodium Chloride, to the ulcer rats. Results Wumo Decoction and Smecta both could increase the ratg secretion of gastric juice （P 〈0.01 ） , Wumo Decoction could highly promote secretion of gastric acid,obviously inhibit activity of pepsin （P 〈0.01 ） , Smecta tad on effect on gastric acid and activity of pepsin（P 〉 0.05 ）Wumo Decoction and Smecta both could lower incidence rate of gastric injury in the Shay g rat,both could protect the rat＇s injury of gastric mucous membrane,compared with Smecta. The proteetive effect of Wumo Decoction on gastric mucous membrane was much better. Conclusion Wumo Decoction can promote secretion of gastric acid,inhibit activity of pepsin,protect gastric mucous membrane,its mechanism could be concerned with stimulating vagus nerve and increasing gastric mucosal blood flow.

关 键 词：消化液 胃黏膜 五磨饮子 

分 类 号：R285.5[医药卫生—中药学]