黄芪对糖尿病大鼠心肌MDA及SOD,GSH-PX,Na^+-k^+ATP酶活性的影响  

The Effect of Astragalus on the Content of MDA and the Activities of SOD,GSH-PX and Na^+-k^+ATPase in Myocardial Tissue of Diabetic Rats

作　　者：阮耀[1] 岳兴如[1] 李晓明[1] 王珍珍[2] 阮翘[2] 

机构地区：[1]南阳医学高等专科学校,河南南阳473000 [2]郑州大学医学院第一附属医院,河南郑州450000

出　　处：《时珍国医国药》2007年第3期593-594,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的观察黄芪对糖尿病大鼠心肌组织MDA含量及SOD,GSH,Na+-k+-ATP酶活性的影响。方法用链脲佐菌素腹腔注射制备糖尿病大鼠模型。正常大鼠、糖尿病大鼠及用黄芪注射液治疗8周的糖尿病大鼠各8只,测定心肌组织丙二醛(MDA)含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、Na+-k+-ATP酶活性。结果黄芪能显著降低糖尿病大鼠心肌组织MDA含量,并能提高心肌组织SOD,GSH-PX及Na+-k+ATP酶活性。结论黄芪对糖尿病大鼠心肌脂质过氧化反应具有抑制作用。Objective To investigate the effects of astragalus on the content of MDA and SOD , GSH - PX and Na^＋ - k ^＋ ATPase in myocardial tissue of diabetic rats. Methods The subjects were 8 normal rats, 8 diabetic rats, and 8 diabetic rats treated with astragalus for 8 weeks. Then we determine the content of MDA and the of SOD, GSH - PX and Na^＋ - k^＋ - ATPase from myocardial tissue of each group. Results The results showed that astragalus could decrease the content of MDA and enhance the of SOD, GSH - PX and Na^＋ - k ^＋ - ATPase （ P 〈 0. 01 ） in myocardial tissue of diabetic rats. Conclusion Astragalus can reduce lioid neroxides in mvocardlal tissue of diabetic rats.

关 键 词：黄芪 糖尿病 心肌 丙二醛 超氧化物歧化酶 谷胱甘肽过氧化物酶 NA^+ - K^+ ATP酶 

分 类 号：R285.5[医药卫生—中药学]