莱菔子水溶性生物碱逆转SHR心血管重构的实验研究  

Experimental Study of Hypotensive Effect of Soluble Semen Raphani Alkaloids in Spontaneous Hypertensive Rats

作　　者：李炳根[1] 李铁云[1] 张国侠[1] 郭鸿雁[1] 李天国[1] 柳静[1] 盖国忠[1] 

机构地区：[1]长春中医药大学,吉林长春130117

出　　处：《长春中医药大学学报》2007年第3期7-8,共2页Journal of Changchun University of Chinese Medicine

基　　金：吉林省科技厅资助课题(课题号:5-28-27)

摘　　要：目的:探讨莱菔子水溶性生物碱对自发性高血压大鼠(SHR)的血压及心血管重构的影响。方法:将40只SHR随机分为5组:空白组、莱菔子水溶性生物碱高、中、低剂量组、卡托普利组,每组8只。采用尾动脉测压法测量血压,于给药8周后,摘取心脏,检测大鼠左室重量及心肌细胞直径、管壁厚／腔径比、管壁面积／腔径比等心血管重构指标。结果:莱菔子水溶性生物碱能明显降低SHR的血压,并使SHR的心室重构得到了改善。结论:莱菔子水溶性生物碱具有明显的降压作用,并对心血管重构具有逆转作用。Objective：To explore the effects of the soluble Semen Raphani alkaloids on spontaneous hypertensive rats （SHR） and on cardiovascular remodeling. Method：Forty SHRs were randomly divided into five groups：untreated control group, the high, middle, low dosage group of the Semen Raphani soluble alkaloids, and Captoril group, with eight rats in each group. Tail- cuff blood pressure（BP） were measured every two weeks. After 8 weeks, the hearts were removed, the left ventricular mass （LVM） were determined. And the diameter of cardiac myocyte, the lumen（R）, wall thickness （WT） and wall area（WA） of small artery; WT/R ratio,WA/R ratio were merured. Result： The soluble alkaloids of Semen Raphani significantly declined the blood pressure of rats. improved the process of cardiovascular remodeling（CR）. Conclusion： The soluble Semen Raphani alkaloids has prominent hypotensive function and can improve the process of cardiovascular remodeling.

关 键 词：莱菔子水溶性生物碱 自发性高血压大鼠 心血管重构 

分 类 号：R285.5[医药卫生—中药学]