N-二茂铁甲酰基甘氨酸的合成研究  

Synthesis of N-Ferrocenylformylglycine

作　　者：胡久荣[1] 梁福沛[2] 

机构地区：[1]上饶师范学院化学系,江西上饶334001 [2]广西师范大学化学化工学院,广西桂林541004

出　　处：《化学世界》2007年第5期291-293,共3页Chemical World

摘　　要：以二茂铁甲酸为原料,经酰氯化,得到二茂甲酰氯.在丙酮与水的混合溶剂中,采用二茂铁甲酰氯与甘氨酸钠反应合成N-二茂铁甲酰基甘氨酸.最佳反应条件为：二茂铁甲酰氯与甘氨酸钠的物质的量比为1：2,反应体系保持pH为8～9,反应温度控制在20～25℃.反应3 h后,用浓盐酸酸化至pH值为1～2,使钠盐转化为N-二茂铁甲酰基甘氨酸,减压抽滤得粗品.经纯化的产品收率为89.0%.标题化合物经元素分析、IR和1H NMR确证结构.Ferrocenylformyl chloride was synthesized by the acylation reaction of ferrocenecarboxylic acid. N- Ferrocenylformylglycine was prepared by treating ferrocenylformyl chloride with glycine in a mixed solvent of acetonewater. The optimum conditions for the reaction were： the molar ratio of ferrocenylformyl chloride and glycine was 1：2, the pH of the solution was kept within 8 - 9 during＇the reaction, the reaction temperature was controlled at 20 - 25℃. After 3 h, the pH of the solution was adjusted to 1 - 2 by hydrochloric acid in order to transformed the sodium salt to the acid. The precipitate was collected by filtration under reduced pressure. The yield was 89.0%. The structure of the target compound was confirmed by elemental analysis, IR and ^1H NMR.

关 键 词：二茂铁甲酰氟 甘氨酸 N-二茂铁甲酰基甘氨酸 合成 

分 类 号：O629.71[理学—有机化学]