甲醛染毒小鼠肝脏、肾脏、脾脏的病理变化  

Pathological changes in liver, kidney and spleen in mice exposed to formaldehyde

作　　者：薛来俊[1] 晓开提.依不拉音 张彦红[2] 

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830054 [2]新疆石油管理局准东勘探开发公司职工医院,阜康831511

出　　处：《中国职业医学》2007年第3期197-198,共2页China Occupational Medicine

摘　　要：目的探索气态甲醛暴露对小鼠肝脏、肾脏及脾脏损害的病理表现。方法80只成年雌、雄各半昆明种小鼠随机分成4组,每组20只,每天2h吸入不同浓度气态甲醛（0-30mg/m^3）持续2周后处死,肉眼及病理切片观察小鼠各脏器的病理改变。结果与对照组相比,中、高剂量甲醛组小鼠肝细胞浊肿、胞浆疏松样变性、气球样变、点灶状坏死、多量病理性核分裂像,汇管区炎细胞浸润、小静脉瘀血;肾脏肾小球充血,肾间质充血、水肿、炎症细胞浸润,管腔内有脱落的细胞和蛋白管型;脾脏白髓、红髓轻度瘀血,红髓内灶状多核巨细胞浸润,并见肉芽肿性病变。结论吸入高浓度甲醛可损伤动物肝脏、肾脏以及脾脏。Objective To explore the pathological changes of formaldehyde（FA） inhalation exposure on liver, kidney and spleen in mice. Methods 80 KM mice were randomly divided into 4 groups. Mice were exposed to FA at the concentration of 0 - 30 mg/m^3 in static chambers 2 hours daily for 14 days. The pathological changes in liver, kidney and spleen were determined through gross necropsy and microslides. Results Compared with the control, there were pathological changes in the livers of mice at high dose groups, including swelling of liver cells, degeneration, balloon-eell change, spot or focal necrosis, abundant nuclear polymorphism and inflammatory infiltration in portal area. The pathological changes of kidney were seen as renal glomerular and interstitium congestion, cutaneous dropsy and inflammatory cell infiltration, exutive cells and protein casts in tubules. The areas of white pulp and red pulp of spleen at high dose group were stagnated with blood. Multinucleated giant cells were infiltrated in the red pulp and granuloma pathological changes were observed in the red pulp. Conclusion When mice were exposed to FA at high concentration, pathological change in liver, kidney and spleen were observed in mice.

关 键 词：甲醛 病理变化 小鼠 

分 类 号：R135.1[医药卫生—劳动卫生]