前列腺素E_1对支气管哮喘的实验研究及临床观察  

THE PGE1 TREATMENT OF BRONCHIAL ASTHMA

作　　者：赵陇[1] 雷军[1] 夏薇[1] 赵振环[1] 

机构地区：[1]河南省医学科学研究所,450052

出　　处：《中国现代医学杂志》1997年第2期1-3,共3页China Journal of Modern Medicine

摘　　要：为了探讨前列腺素E1（PGE1）治疗支气管哮喘的机理和临床疗效，从自由基医学研究的角度进行实验表明PGE1对哮喘豚鼠有明显的保护作用，显著延长引喘潜伏期，并抑制哮喘豚鼠肺组织脂质过氧化物（LPO）水平的升高，从而进一步阐明PGE1解痉平喘的机理。该文还报告了2例用各种方法治疗均不能收效的顽固性支气管哮喘病人，经用PGE1静脉点滴治疗后，哮喘症状缓解，肺功能明显改善，疗效显著。说明PGE1对治疗支气管哮喘，尤其对治疗顽固性哮喘是一种具有发展前景的药物。In order to study the therapeutic mechanism and effects of PGE1 on bronchial asthma, an experiment and clinical observations have been conducted. We found PGE1 prolongs the induction period of histamine induced wheezingand prevents LPO Ievels from increasing in the lung tissue of asthmatic guinea pigs. Two cases with difficult theraPeutic asthma are also reported in this paper. After intravenously guttae PGE1 treatment, lung function improvedsignificantly and clinical symptoms disappeared. These results suggest that PGEl could be clinically valuable as atreatment of bronchial asthma.

关 键 词：前列腺素E1 脂质过氧化物 哮喘 实验研究 

分 类 号：R562.25[医药卫生—呼吸系统]