5-羟色胺转运体、G蛋白β3亚单位基因多态性与抑郁症的相关性研究  

Study of the Relationship Between 5-HTTLPR and G-protein β3 Subunit Polymorphisms and Depression

作　　者：曹美群[1] 胡随瑜[1] 张春虎[1] 李云辉[1] 夏大胜[2] 

机构地区：[1]中南大学湘雅医院中西医结合研究所,湖南长沙410008 [2]天津第一中心医院,天津300000

出　　处：《中国临床心理学杂志》2007年第3期318-320,317,共4页Chinese Journal of Clinical Psychology

基　　金：国家"十五"科技攻关项目资助(编号2001BA701A22)

摘　　要：目的:观察5-羟色胺转运体基因(5-HTTLPR)和G蛋白β3亚单位基因(GNβ3 C825T)多态性在中国抑郁症患者中的分布情况及特点,探讨抑郁症发生的遗传机制。方法:采用聚合酶链反应和限制性片段内切酶的方法检测了180例抑郁症患者(其中男性84例,女性96例)及156例健康人对照组的5-HTTLPR和GNβ3 C825T基因多态性。结果:5-HTTLPR和GNβ3 C825T基因多态性在两组人群中的分布差异均有显著性,抑郁症组的5-HTTLPR SS基因型及S等位基因频率和GNβ3 825TT基因型及T等位基因频率均高于对照组(P<0.05)。进一步联合基因型分析显示:同时具有5-HTTLPRS和GNβ3 825T等位基因者患抑郁症的相对危险度(OR=3.25,P=0.001)比单独具有5-HTTLPRS等位基因(OR=1.817,P=0.01)或GNβ3 825T等位基因者高(OR=2.214,P=0.001)。结论:5-HTTLPR和GNβ3 C825T基因可能均是抑郁症的易感基因,且显示这两个基因在抑郁症的发病中存在微效协同作用。Objective： To assess whether 5-HTTLPR and GNβ3 C825T gene polymorphisms are associated with depression and explore the genetic mechanism of the pathogenesis of depression. Methods： The genotypes were determined with polmerase chain reaction and allele-specific restriction enzyme analysis. Depression patients （n=180） and sex and age-matched controls （n=156） were included in this study. Results： The frequency of 5-HTTLPR SS genotype, S allele and GNβ3 825TT genotype, 825T allele were significantly higher in the depression group than in the controls （P〈 0.05）. Combined genotype analysis showed that individuals with both 5-HTTLPR S and GNβ3 825T allele （OR=3.25 ,P=- 0.001 ）had a higher risk than those with 5-HTTLPR S allele （OR=1.817,P=0.01） or GNβ3 825T allele （OR=2.214,P= 0.001 ） only for depression. Conclusion： The 5-HTTLPR and GNβ3 C825T polymorphisms are predisposing genes of depression. Our data also suggest a significant interaction between the 5-HTTLPR S allele and GNβ3 825T allele in depression.

关 键 词：抑郁症 基因多态性 5-HTTLPR GNβ3 C825T 

分 类 号：R395.1[哲学宗教—心理学]