中国汉族人血栓性疾病与抗活化蛋白C关系的系统评价  

Systematic Evaluation of Thrombotic Disease and Activated Protein C Resistance in Chinese Han Nationality

作　　者：王兵[1] 张武臣 张畔[1] 曹书华[1] 

机构地区：[1]天津市第一中心医院急救医学研究所,300192 [2]山东省临邑县人民医院

出　　处：《中国微循环》2007年第3期154-157,共4页Journal of Chinese Microcirculation

摘　　要：目的 评价中国人血栓性疾病与抗活化蛋白C（Activated Protein C Resistance，APCR）之间的关系。方法 全面检索相关文献，剔除不符合要求的文献。数据采用软件RevMan4.2进行统计分析。结果 1996-2006年之间总共10个临床研究可满足入选标准，计1230例研究对象，对照人群APCR（＋）发生率为2.86%，而血栓形成患者APCR（＋）发生率为22.31%。综合OR=6.70（95%CI，4.56-9.83）。结论 中国汉族人血栓性疾病与抗活化蛋白C密切相关。Objective To evaluate the association between the disease of thomobosis and the activated protein C resistance （APCR） of Chinese. Methods A systematic review of all the relevant randomized controlled trials were performed while poor studies were excluded. Statistic analysis was conducted by using RevMan 4.2 and the risk of publication bias was estimated. Results Ten clinical trials of 1230 participants were admitted from 1996 to 2006. The incidence rate of APCR （ ＋ ） in control group is 2.86% but 22.31% in thrombosis group. Meta-analysis indicated that odds ratio was 6.70 （95% confidence interval[4.56 -9.83], P 〈0.01 ） compared with controls. Conclusion The disease of thomobosis and the APCR are closely related in Chinese Han nationality.

关 键 词：抗活化蛋白C 血栓形成 系统评价 

分 类 号：R446.11[医药卫生—诊断学]