脂联素与代谢综合征相关性及生活方式的干预作用  

Assosiation of Adiponectin with Metabolic Syndrome and Effects of Lifetyle Intervention

作　　者：倪子琴 骆秉铨 徐祥英[1] 王绪山[1] 朱一娥 

机构地区：[1]江苏省灌云县人民医院,222200 [2]徐州市心血管病研究所

出　　处：《中国微循环》2007年第3期191-194,共4页Journal of Chinese Microcirculation

摘　　要：目的研究血清脂联素水平与代谢综合征组成部分之间的相关性,并评价生活方式干预MS患者对血清脂联素的影响。方法从健康体检人群中筛查出代谢综合征患者96例,随机分为生活方式干预(运动,饮食)组48例和对照(健康教育)组48例。另设正常对照组35例,测定代谢综合征相关的测量参数和生化指标以及血清脂联素水平,分析生活方式干预1年后各项指标变化情况。结果代谢综合征组血清脂联素水平明显低于正常对照组(4.79±1.09对10.92±2.15,P<0.01),且脂联素与WC、FBG、DBP、TG呈负相关,与HDL-C呈正相关。生活方式干预1年后,代谢综合征相关组成部分均有明显改善(P<0.05或P<0.01),血清脂联素与基线值比较明显升高(6.68±1.59对4.73±1.27,P<0.01)。结论代谢综合征患者血清脂联素水平减少,且与代谢综合征各组成部分相关联,提示脂联素可以作为MS新的标志物。持久的生活方式干预能升高血清中脂联素水平,有助于防治代谢综合征相关疾病。Objective To study assosiation beteween serum adiponectin level and components of metabolic syndrome（MS） and their effects by lifetyle intervention. Methods 96 subjects with MS from healthy participants were screened, which were randomly divided into intervention（ physical training , diet control） group （n =48）, and control （health education ）group （n =48）, detecting MS-relative indexes of measurement and biochemistry as well as adiponectin in serum. Results The serum adiponectim level was significantly decreased（4.79 ± 1.09 vs 10.92 ±2.15, P 〈0.01）, and adiponectin was positively related to HDL-C, but negtively to WC , FBG, DBP, TG. After one year of the lifetyle intervention, in MS group, the mean body weight reduction was 9% of the initial weight , the MS-relative components including increased WC, FBG, DBP, TG and decreased HDL-C were all improved, meanwhile, the adiponectin level was markedly higher than the base state （6.68±1.59 vs 4.73 ± 1.27, P 〈 0.01）. Conclusion In subjects with MS, the serum adiponectin level was significantly decreased, and it was associated with all components of MS, suggesting that serum adiponec- tin may act as a new marker of MS. Improved MS-related components and increased adiponectin level were gained by lifetyle intervention, which may be helpful in preventing and treating MS-related diseases.

关 键 词：脂联素 代谢综合征 生活方式 体育锻炼 

分 类 号：Q513.5[生物学—生物化学] R589[医药卫生—内分泌]