维生素E对老年雌性大鼠抗氧化能力及海马神经元凋亡的影响  

Effect of vitamin E on antioxidation capacity and hippocampus neuron apoptosis in senile female rats

作　　者：孔亚坤[1] 焦润生[1] 卢长柱[1] 金香兰[1] 赵新宇[1] 王月鹏[1] 姚兰春[1] 

机构地区：[1]哈尔滨医科大学生理学教研室,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2007年第3期199-201,共3页Journal of Harbin Medical University

摘　　要：目的探讨维生素E(VE)对老年雌性大鼠抗氧化作用和海马神经元凋亡调节作用。方法用生化法测定血清总超氧化物歧化酶(T-SOD)和丙二醛(MDA);用TUNEL法检测海马神经元凋亡。结果与老年对照组相比,各VE组T-SOD活力有所升高但无显著性差异;各VE组、雌激素组MDA含量均显著降低(P<0.01);各VE组、雌激素组神经元凋亡百分率均显著降低(P<0.01)。结论在老年雌性大鼠中,VE具有较强的对抗自由基损伤作用,并可显著降低神经元凋亡的发生率。Objective To observe the effect of vitamin E（VE） supplementation on antioxidation capacity and hippocampus neuron apoptosis in senile female mrs. Methods The levels of total superoxide dismutas （T- SOD） and malondialdelyde （MDA） in serum were measured by biochemical method; neuron apoptosis in hippocampus was detected by TUNEL assay. Results Compared with senile control group, the activities of T-SOD were not significantly increased in VE groups; the levels of MDA were significantly decreased both in VE groups and in estrogen group （ P 〈 0.01 ）. Neuron apoptosis rotes were decreased significantly both in VE groups and in estrogen group （P 〈 0.01 ）. Conclusion VE can defend the injury of free radical and significantly reduce the apoptosis in senile female rats.

关 键 词：维生素E 氧化应激 超氧化物歧化酶 丙二醛 细胞凋亡 

分 类 号：R339.2[医药卫生—人体生理学]