未变性乳清蛋白对支气管哮喘儿童红细胞抗氧化酶系统的影响  

Antioxidative protective effect of undenatured whey protein on asthma children's erythrocyte

作　　者：庞戈红[1] 方美云[1] 谭娴玲[1] 林耀棠[2] 

机构地区：[1]广东省珠海市妇幼保健院儿科,519000 [2]暨南大学第三附属医院检验科

出　　处：《中国妇幼保健》2007年第18期2504-2505,共2页Maternal and Child Health Care of China

摘　　要：目的:观察未变性乳清蛋白对支气管哮喘儿童抗氧化酶系统的影响。方法:采集30例健康儿童血标本;收集56例哮喘患儿资料,随机分为治疗组30例,采用未变性乳清蛋白加普米克(布地奈德气雾剂)治疗;对照组26例,单用普米克治疗。分别测定健康儿童、对照组及治疗组儿童红细胞浆内总谷胱甘肽(GSH)含量及谷胱甘肽过氧化物酶(GSH-PX)活性。结果:支气管哮喘儿童红细胞总GSH含量较健康儿童减少,GSH-PX活性降低;治疗组较对照组红细胞GSH含量及GSH-PX活性有明显提高。结论:未变性乳清蛋白能有效提高支气管哮喘患儿红细胞浆中GSH水平,增加GSH-PX活性。Objective： To investigate the antioxidative effect of undenatured whey protein on asthma children＇s erythrocyte. Methods： Arterial blood sample were taken from 30 healthy children. 56 asthma children＇s information were collected and randomly divided into two groups： the treatment group had 30 cases which were given undenatured whey protein and Pulmicort （Budesonide Aerosol）, the control group had 26 cases which were given Pulmicort . Cord blood samples of healthy children and two groups of asthma children were taken to determine reduced glutathione （GSH） and activity of glutathione peroxidase （ GSH - PX） in erythrocyte intracytoplasm. Results ： Reduced glutathione and activity of glutathione peroxidase in asthma children were lower than that in healthy children, and the treatment group＇s were higher than the control group＇s. Conclusion ： Reduced glutathione and activity of glutathione peroxidase with undenatured whey protein are increased.

关 键 词：未变性乳清蛋白 谷胱甘肽 红细胞 支气管哮喘 

分 类 号：R725.6[医药卫生—儿科]