种植窗期子宫内膜类型和白血病抑制因子的关系  

Relations between leukemia inhibitory factor(LIF) and endometrium on the window of implantation in women

作　　者：李素春[1] 闫彩平[1] 苏芸[1] 聂琼英[1] 陈瑞玲[1] 钟兴明[1] 汪玉宝[2] 

机构地区：[1]广东省计划生育科学技术研究所,510600 [2]上海计划生育科学技术研究所

出　　处：《中国妇幼保健》2007年第18期2565-2567,共3页Maternal and Child Health Care of China

摘　　要：目的：研究种植窗期子宫内膜类型和白血病抑制因子（LIF）的关系。方法：对94例不孕患者于排卵后7~9天行B超测量子宫内膜的厚度、宫腔镜观察子宫内膜血管网及腺体的形态分布、酶连免疫吸附实验测定宫腔冲洗液中LIF浓度。结果：Ⅰ组（腺体开口小或内膜血管呈点状或片状分布）不孕患者的平均年龄高于Ⅱ组（腺体开口大、极度扩张呈指环状，且内膜血管呈网状分布）（P〈0.01），不孕年限无差异（P〉0.05）；原发不孕和继发不孕患者子宫内膜类型无差异（P〉0.05）；Ⅰ组和Ⅱ组患者的子宫内膜厚度无差异（P〉0.05）；Ⅰ组宫腔冲洗液中LIF浓度为（15.367±16.285）pg/ml，Ⅱ组中LIF浓度为（71.583±54.233）pg/ml，高于Ⅰ组（P〈0.01）。结论：种植窗期子宫内膜类型与不孕患者的年龄及宫腔液中LIF含量有关，推测可能内膜发育差的不孕患者子宫内膜上LIF基因表达发生变异，不能分泌正常量的LIF蛋白，导致子宫内膜腺体和血管网发育不良，胚胎到达宫腔内无法着床或早期流产，这可能是影响种植窗期子宫内膜发育的分子生物学基础之一。Objective： Exploring the possible relations between leukemia inhibitory factor （LIF） and endometrium on the window of implantation in women. Methods： 94 infertile women on the window of implantation were examined , including the tlfickness of endometrium by B ultrasound , the endometrial gland form and capillary vessel distribution by hysteroscopy and the level of LIF in uterine fluid by enzyme hnked immunosorbent assay （ELISA） . Results： The average age of group Ⅰ （the opening of the gland duct was little or the capillary vessel was distributed like dot or sheet ） was elder than group Ⅱ （ the opening of the gland duct was big enough like a ring and the capillary vessel was distributed like vet） （P 〈 0. 01 ） . There was no difference in infertile years and also no difference in type and tlfickness of endometrium between the two groups （ P 〉 0.05） . The level of LIF in uterine fluid of group Ⅰ （ 15. 367 ± 16. 285pg/ml） was higher than group Ⅱ （71. 583 ± 54. 233 pg/ml） （P 〈 0. 01 ） . Conclusion ： The expression type of endometrium on the window of implantation is relative with age and the level of LIF in uterine fluid. It is concluded that the infertile women with poor endometrium cant secret normal amount of LIF protein because the LIF gene in endometrium is abnormal which results failure in implantation or early abortion. This maybe one of the molecular biology factor which affects the endometrium growth on the window of implantation.

关 键 词：种植窗期 子宫内膜 不孕 白血病抑制因子 

分 类 号：R711.6[医药卫生—妇产科学]