脊髓Ⅱ号对大鼠损伤脊髓轴浆运输的影响  

Effect of Spinal Cord Ⅱ on Axoplasmic Transport in Injured Spinal Cord of Rat

作　　者：刘卫东[1] 韩凤岳[1] 景向红[2] 

机构地区：[1]中国中医研究院骨伤科研究所,100700 [2]中国中医研究院针灸所

出　　处：《中国骨伤》1997年第3期15-17,共3页China Journal of Orthopaedics and Traumatology

摘　　要：选取24只Wistar大白鼠，将其中18只制成胸髓右半侧横断损伤的大鼠模型，分别以脊髓Ⅱ号方剂、激素、生理盐水灌喂治疗。未造模的6只大鼠作为正常组，常规喂养。一个月后，注入辣根过氧化物酶（HRP），检测路经损伤区的上下行神经传导束始发核团中的标记细胞。发现脊髓Ⅱ号组HRP标记细胞数明显多于另两组，而与正常大鼠相比没有统计学上的显著差异。说明脊髓Ⅱ号方剂在恢复损伤传导来神经纤维的正常连续性，恢复神经元轴浆运输，促进神经细胞修复再生方面，有显著的效应。Experimental models of right hemitransection of thoracic spinal cord were made in 18 Wistar rats and divided random1y into three groups: treated with Chinese herbsn Spinal Cord Ⅱ' (SC Ⅱ), hydrocortisone, and normal saline, respectively. 6 intact rats were fed as usual. One month later, horseradish peroxidase (HRP) was injected into experimental rats. and the HRP labelled neurons in the originating nuclei of ascending and descending nerve fiber bundles passing through the injured area were examined and counted undermicroscope. It was found that the number of HRPlabelled neurons in SC Ⅱ group was prominently greater than that in hydrocortisone group and saline group (P<0. 05), and there was no prominent difference in thenumber of HRP Labelled neurons between SC Ⅱ groupand normal group (P>0.05). It was suggested thatSpinal Cord Ⅱ can promote the recovery of normalcontinuity of injured nerve fibers, the axoplasmictransportation,and the regeneration of neurons in injuredspinal cord.

关 键 词：脊髓损伤 轴浆运输 脊髓Ⅱ号 大鼠 

分 类 号：R289.5[医药卫生—方剂学] R285.5[医药卫生—中药学]