流动敏感交互反转恢复与MR磁敏感对比剂动态增强技术评价颅内肿瘤血流灌注的对照研究  

Comparison of flow-sensitive alternating inversion recovery and dynamic susceptibility contrast MR perfusion technique in evaluating intracranial tumor vascularization

作　　者：张凯[1] 李传福[1] 刘影[2] 冯德朝[1] 孟祥水[1] 郑金勇[1] 丛培新[1] 

机构地区：[1]山东大学齐鲁医院放射科,山东济南250012 [2]安徽省立医院放射科,安徽合肥230001

出　　处：《山东大学学报（医学版）》2007年第6期621-624,628,共5页Journal of Shandong University:Health Sciences

摘　　要：目的:比较流动敏感交互反转恢复(FAIR)与MR磁敏感对比剂动态增强(DSC-MR)技术评价颅内肿瘤血流灌注的价值。方法:对33例颅内肿瘤患者行FAIR和DSC-MR脑灌注成像,分别测定FAIR值和脑血容量(CBV)值,对其进行相关分析,并比较良、恶性胶质瘤之间FAIR值与CBV值之间的差异。结果:FAIR值与CBV值之间呈正线性相关(r=0.450,P=0.009)。良性胶质瘤CBV值平均为164.31±109.20,恶性胶质瘤的CBV值平均为365.12±177.41,两者之间差异有统计学意义(Z=-2.213,P=0.027)。良性胶质瘤的FAIR值平均为37.83±46.07,恶性胶质瘤的FAIR值平均为101.90±103.83,两者之间差异有统计学意义(Z=-2.021,P=0.043)。结论:FAIR技术无需对比剂,所提供的血流灌注信息与DSC-MR相符,有较大的临床应用潜力。Objective： To compare the effects of flow-sensitive alternating inversion recovery （FAIR） and dynamic susceptibility contrast MR （DSC-MR） perfusion technique in evaluating intracranial tumor vascularization. Methods： Thirty-three patients suffering from intracranial tumors were determined by using the FAIR and DSC-MR perfusion techniques. The values of FAIR and CBV were recorded and analyzed by the linear correlation analysis method. The values of FAIR and CBV between benign and malignant gliomas were statistically analyzed. Results： There was a positive linear correlation between FAIR and CBV（ r = 0.450, P= 0.009）. The difference of the CBV value between benign and malignant gliomas was statistical （ Z = - 2. 213, P = 0. 027）. So was that of the FAIR value （ Z = - 2. 021, P = 0.043）. Conclusion： FAIR does not need a contrast agent and could offer some comparable perfusion information to DSC-MR technique to clinicians, so it has the potential to be clinically applied.

关 键 词：磁共振成像 血液灌注 自旋标记物 中枢神经系统肿瘤 

分 类 号：R445.2[医药卫生—影像医学与核医学]