除湿止痒合剂治疗湿疹的临床研究  

Clinical Research on Chushi Zhiyang Mixture Curing Eczema

作　　者：宋瑜[1] 李咏梅[1] 马绍尧[1] 冯国强[1] 陈妙善[1] 顾敏婕[1] 

机构地区：[1]上海中医药大学附属龙华医院皮肤科,上海200032

出　　处：《中国中西医结合皮肤性病学杂志》2007年第2期70-72,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

基　　金：上海市卫生局中药制剂新药开发项目(沪卫中验字[2005]第9号)

摘　　要：目的评价除湿止痒合剂治疗湿疹的有效性和安全性。方法134例湿疹患者,随机分为治疗组67例,口服除湿止痒合剂;对照组67例,口服肤痒冲剂,以2周为1个疗程,疗程结束后观察两组疗效及安全性指标。结果①治疗组总有效率86.6%,对照组总有效率67.2%,治疗组明显优于对照组(P<0.01)。②单项症状疗效上,两组患者在各项指标评分上均有明显改善(P<0.01),同时在改善皮疹形态、皮疹面积以及瘙痒起效时间等单项指标上,治疗组明显优于对照组(P<0.05,或P<0.01)。③两组患者在中医症候总评分上均有明显改善(P<0.01),“心烦失眠”、“小便黄赤”两项单项症候改善情况,治疗组优于对照组(P<0.05)。④未发生和试验药物有关的不良反应。结论除湿止痒合剂治疗湿疹有显著疗效,能迅速缓解临床症状,显著改善皮肤损害,是一种安全有效治疗湿疹的中药制剂。Objective To evaluate the effectiveness and safeness of Chushi Zhiyang Mixture curing eczema. Methods 134 eczema patients are randomly divided into 2 groups. 67 patients in treatment group orally taking Chushi Zhiyang Mixture; 67 patients in comparison group orally taking Fuyang Granule. Observe curative effect and safeness after treating for two weeks. Results ① In treatment group, total rate of effectiveness is 86.6% ; while of the comparison group is 67.2%. The effect of the treatment group is apparently better than that of the comparison group（P〈0.01 ）. ②As to the curative effect of individual symptoms, there is apparent improvement （P〈0.01） in patients of both groups with regard to all scoring factors. At the same time, the treatment group is apparently better than the comparison group （P〈0.05 or P〈0.01 ）in individual scoring factors like tetter shape improvement. ③There is apparent improvement （P〈0.01）in patients of both groups with regard to traditional Chinese medicine（TCM） symptom. Treatment group is apparently better than comparison group （P〈0.05）in the improvement of “vexation and insomnia”, “deep-coloured urine”. ④It shows no adverse reaction pertinent to the tested drug. Conclusion Chushi Zhiyang Mixture has apparent curative effect to eczema, and it can alleviate clinic symptom in a short time, apparently amends skin damage. The drug proves to be an effective and safe TCM pharmaceutics in curing eczema.

关 键 词：湿疹 中医药疗法 除湿止痒合剂 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]