扁平苔藓表皮中P物质的表达  

Expression of Substance P in Epidermis of Lichen Planus

作　　者：张进[1] 白莉[2] 樊娟丽 

机构地区：[1]中国人民解放军第一七四医院,厦门361003 [2]山西医科大学第一附属医院,太原030001 [3]山西省运城中心医院,运城044000

出　　处：《中国中西医结合皮肤性病学杂志》2007年第2期82-84,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的检测神经肽P物质(SP)在扁平苔藓(LP)表皮中的表达,并探讨其在发病中的作用。方法采用免疫组化技术检测30例扁平苔藓皮损和30例正常人皮肤组织中SP的表达。结果扁平苔藓表皮中有SP表达,主要分布在表皮棘细胞层,部分颗粒层、角质层也有表达;正常皮肤中也有SP表达,主要分布于表皮基底层。扁平苔藓表皮细胞中SP的表达水平高于正常对照组,其差异有统计学意义(P<0.05)。结论SP与扁平苔藓皮损的发生及发展有一定的关系。Objective To examine substance P（SP） in lichen planus lesions, and investigate its function in pathogenesis of lichen planus（LP）. Methods Use immunohistochemical technique to examine the expression of SP in lesions of 30 LP patients and 30 normal skins. Results SP was distributed in epidermis of lichen planus. The expression of SP in normal skins were mainly stained in basal cell layer. Compared with the normal skins, the expression level of SP in lesions of lichen planus was significantly higher （P〈O.05）. Conclusion SP might play a certain role in the pathogenesis and development of lichen planus.

关 键 词：P物质 扁平苔藓 免疫组化 

分 类 号：R758.65[医药卫生—皮肤病学与性病学]