利福霉素B氧化生成利福霉素O的工艺研究  

Study on the Preparation of Rifamycin O by Oxidation of Rifamycin B

作　　者：涂志英[1] 武斌[2] 朱家文[2] 

机构地区：[1]三峡大学化学与生命科学学院,湖北宜昌443002 [2]华东理工大学化学工程研究所,上海200237

出　　处：《化学世界》2007年第6期366-369,348,共5页Chemical World

摘　　要：对利福霉素B氧化生成利福霉素O的反应体系和操作条件进行了实验研究。通过实验研究发现,NaNO2为适宜的氧化剂,反应介质为甲醇和pH4.62醋酸盐缓冲液的混合体系,适宜反应温度10℃,反应时间1h。在适宜反应条件下,产物收率达到80%,而纯度达到92%以上。The reaction system and operation conditions for the oxidation of rifamycin B to rifamycin O were studied. A suitable process of oxidation of rifamycin B was found. Rifamyein B can be oxidized with sodium nitrite as oxidant in the mixture of methanol and acetate buffer （pH 4.62）. The oxidation reaction can be completed within 1 h at 10 ℃. Under the optimal conditions, the oxidation product （rifamycin O） can be obtained with a yiele of 80% and a purity over 92%.

关 键 词：利福霉素B 利福霉素O 氧化 

分 类 号：R978.1[医药卫生—药品]