通痹灵治疗强直性脊柱炎临床疗效评价  

Effect of Tongbiling for ankylosing spondylitis

作　　者：李建松[1] 张静[2] 林昌松[2] 陈纪藩[2] 

机构地区：[1]深圳市宝安区中医院,广东深圳518133 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《临床医药实践》2007年第6期453-455,共3页Proceeding of Clinical Medicine

摘　　要：目的:评价通痹灵治疗活动期强直性脊柱炎(AS)的临床疗效及毒副反应。方法:采用随机对照单盲双模拟的方法,将69例活动期AS分为通痹灵治疗组(36例)和吲哚美辛对照组(33例)。通痹灵组口服通痹灵A,每次6片,每日3次,吲哚美辛组口服通灵A(含吲哚美辛25mg)每次6片,每日3次。结果:总有效率两组间差异无显著性(P>0.05),但通痹灵组控显率优于吲哚美辛组(P<0.01);两组治疗前后疼痛积分、晨僵时间和指地距离改善明显(P<0.01或<0.05),扩胸度和枕墙距均无改善(P>0.05)。通痹灵组关节肿胀积分、Schober试验、整体功能、实验指标(ESR、CRP、PLT、IgG、IgA、IgM)和骶髂关节影像积分均有明显改善(P<0.01);吲哚美辛组关节肿胀积分、整体功能、实验指标和骶骼关节影像积分无改善(P>0.05)。两组治疗后比较:通痹灵组改善肿胀积分、晨僵时间、指地距离、整体功能和实验指标(除CRP外)优于吲哚美辛组(P<0.01或<0.05);通痹灵组未发现明显不良反应。结论:通痹灵对活动期AS具有改善临床症状、体征和实验指标的作用,且对AS骨质损害具有保护作用,未发现不良反应。Objective：To evaluate the therapeutic effect of Tongbiling for ankylosing spondylitis （AS） and to study its side and toxic effects. Methods：Randomized controlled and single-blind double-mimic trial was applied in 69 cases of AS. The cases were allocated to two groups. Thity-Six cases were treated with Tohgbiling group （Tongbiling ⅠA）, 6tablets each time ,three times per day and thirty-three cases were treated with indomethacin group （Tongbiling Ⅱ A） （containing indomethacin 25 mg）. Results：The difference of total effective rate in the two groups was not significant （P〉 0.05）, but the effective rate of symptom reliefin Tongbiling group was superior to that in indomethacin group（P〈0. 01 ）. The pain scoring, time of morning stiffness, middle-finger-to-floor distance were improved after treatmend in the trwo groups（P〈0.05 or P〈0. 01）while chest expanding activity and occiput-to-wall distance were not improved （P〉 0.05）. Joint swelling, schober lest, general function, laboratory lest （ESR, CRP, PLT, IgG, IgA and IgM ） , and scoring of X - ray image of sacra - iliac joint differ singnificantly after treatment in Tongbiling group （ P 〈0.01）. While not singnificant in indomethacin group （P〉0.05）. The improvement of the above imdexes except CRP in Tongbiling IA was superior to that in Tongbiling Ⅱ A （P〈0.05 or P〈0.01）. No obvious abverse reaetion was found Tongbiling ⅠA. Conclusion ：Tongbiling can improve the symptoms ,singns and laboratory indexes of AS ,and can prevent AS patients from bone destruction.

关 键 词：通痹灵 强直性脊柱炎 疗效评价 

分 类 号：R593.23[医药卫生—内科学]