采用一步制粒法影响清开灵颗粒孔隙率因素的探讨  

Study on the Factors of Influencing Qingkailing Granules Porosity with One-step-granulating

作　　者：邢继芳 

机构地区：[1]远达药业集团哈尔滨一洲制药有限公司,150086

出　　处：《黑龙江医药》2007年第4期344-345,共2页Heilongjiang Medicine journal

摘　　要：目的:探讨一步制粒机中影响清开灵颗拉孔隙率的因素;方法:采用一步制拉法对影响孔隙的因素进行试验;结果:对孔隙率影响大小的顺序为供液速率>排风频率>进风温度,并在优选的条件下试硷,发现润湿粘附剂的浓度与孔隙率成反比;结论:采用一步制粒技术可形成孔隙率大的颗粒,大大提高了药物的溶出速率。Objective： In order to discuss the factor of one - step - granulating＇s influence on the Qingkailing granules porsity. Methods： We had an experiment with one - step - granulating. Results： the sequence of influencing porosity is that the rate of supplying liquid 〉 the frequency of obviating wind 〉 the temperature of putting in wind, the chroma of wetting agent conglutination and porosity show inversc ratio under the test of handpicked condition. Conclusion ：with one- step - granulating we could get the granules with much larger poroity to raise the rate of dissolution.

关 键 词：一步制粒 孔隙率 清开灵颗粒 工艺研究 

分 类 号：TQ461[化学工程—制药化工]