含T_3温血停搏液对心功能及冠脉内皮细胞功能的影响  

Effects of T 3 in Warm Blood Cardioplegia on Left Ventricular and Coronary Vascular Endothelial Function

作　　者：朱亚彬[1] 顾懋栋[1] 吴熹[1] 

机构地区：[1]南京铁道医学院附属医院胸心外科

出　　处：《南京铁道医学院学报》1997年第1期20-22,共3页Journal of Nanjing Railway Medical College

摘　　要：目的：观察温血停搏液中加入０．６ｍｇ／ＬＴ３对停搏心肌能量代谢、左心收缩及舒张功能、心肌酶谱及冠状动脉内皮细胞功能的影响。方法：观察离体鼠心停搏前后左室收缩压（ＬＶＳＰ）、左室收缩压力微分（ＬＶ＋ｄｐ／ｄｔｍａｘ）、左室舒张压力微分（ＬＶ－ｄｐ／ｄｔｍａｘ）及心肌氧耗量（ＭＶＯ２），测定鼠心复跳后１ｍｉｎ冠状静脉窦流出液中乳酸脱氢酶（ＬＤＨ）、肌酸磷酸激酶（ＣＰＫ）含量。观察乙酰胆碱（Ａｃｈ）和硝普钠灌注冠状动脉后的血管阻力变化。结果：实验组ＬＶＳＰ、ＬＶ＋ｄｐ／ｄｔｍａｘ及ＬＶ－ｄｐ／ｄｔｍａｘ的恢复均优于对照组（Ｐ＜０．０５），ＭＶＯ２、ＬＤＨ及ＣＰＫ含量无差别（Ｐ＞０．０５），实验组因Ａｃｈ所致的冠脉血管阻力下降较对照组明显。结论：Ｔ３具有促进停搏心肌功能恢复、降低冠状血管阻力的作用而不影响心肌氧耗量。Objective:This study aims at evaluating the effects of continuous normothermic blood cardioplegia which contained 0.6 mg/L T 3 on left ventricular systolic and diastolic function,myocardial energic metabolism and coronary vascular endothelial function.Method:The isolated working rat heart model was used to observe the change in left ventricular systolic pressure (LVSP),LV+dp/dt max ,LV-dp/dt max and myocardial oxygen consumption(MVO 2).LDH and CPK concentration in coronary sinus effluent was tested after 1 minute reperfusion.1×10 -5 mol/L acetylcholine(Ach) and 1×10 -6 mol/L sodium nitroprusside(SNP) were used to study coronary vascular resistance.Result:LVSP,LV+dp/dt max and LV-dp/dt max in experimental group had a better recovery than in control group.There was no difference in regard to LDH,CPK and MVO 2 between both groups studied.Conclusion:T 3 plays a contributory role in left ventricular function recovery of arrested heart.It reduces coronary vascular resistance without additional myocardial oxygen consumption. 〗WT5HZ〗

关 键 词：T3 温血停搏液 心肌保护 冠状动脉 

分 类 号：R654.2[医药卫生—外科学]