新型除草剂ZJ0862的研究与开发  

Research and Development of the Novel Herbicide ZJ0862

作　　者：徐小燕[1] 彭伟立[1] 陈杰[1] 台文俊[2] 刘燕君[1] 傅荣幸[1] 

机构地区：[1]浙江化工科技集团有限公司,杭州310023 [2]中国科学院上海有机化学研究所,上海200032

出　　处：《农药学学报》2007年第2期117-121,共5页Chinese Journal of Pesticide Science

基　　金：国家"十五"科技攻关项目(2004BA308A23-1)

摘　　要：以水杨醛、3,4-二氯苯胺和4,6-二甲氧基-2-甲砜基嘧啶为原料合成了新型除草剂ZJ0862[N-（3,4-二氯苯基）-6-氯-2-（4,6-二甲氧基-2-嘧啶氧基）苄胺],其结构经^1H NMR、MS、IR和元素分析确证。室内生物测定试验表明,ZJ0862在有效成分60g/hm^2剂量下,对水田重要杂草稗草和异型莎草的抑制率达90%以上;在45g/hm^2剂量下,对看麦娘、野燕麦、狗尾草等15种田间常规杂草的抑制率达85%-100%,杀草谱较广;田间试验结果显示,ZJ0862在150g/hm^2剂量下对移栽水稻安全,且在60-90g/hm^2剂量下对水田主要杂草水苋菜、陌上菜、异型莎草等的防效达81.3%-98.4%。毒理学评价结果显示,该药剂为低毒、无刺激、弱致敏和致突变阴性。ZJ0862具有高效、低毒、安全的特点,在移栽水田将具有较好的开发前景。A novel herbicidal compound ZJ0862 was synthesized from salieylic aldehyde ,3,4-dichloroaniline and 4,6-dimethoxy-2-methyl sulfonyl pyrimidine. The chemical structure of the compound was confirmed by ^1H NMR, MS, IR and elemental analysis. The bioassay indicated that ZJ0862 had good herbicidal activity to the important weeds in rice field, such as Echinochloa crus-galli and Cyperus difformis （inhibition rate 〉 90% ）. And the inhihition rate for 15 common weeds such as Alopecurus aequalis,Avena fatua,Setaria viridis were 85% -100% at 45 g/hm^2. It had broad spectrum weed control. The field trial showed that the compound （ 150 g/hm^2 ） was safe to transplanted rice, and had good efficacy （81.3% -98.4% ） to the mainly weeds in paddy,such as A. baccefera and L. procumbens, under the concentration of 60 - 90 g/hm^2. Toxicological tests showed it was low toxicity, non irritating, slightly sensitisation and negative mutagenicity. ZJ0862 had good potential to dovelop in transplanted rice.

关 键 词：嘧啶苄胺类先导结构 ZJ0862 研究与开发 水稻田除草剂 

分 类 号：R392.11[医药卫生—免疫学]