石棉作业女工血脂质过氧化与抗氧化活性的研究  

Study on plasmic lipid peroxidation and its anti-oxide activity in chrysotile-exposed femate workers

作　　者：肖国兵[1,2] 马藻骅[1,2] 陈志先 邵迪初 邱华士[1,2] 孙新媛[1,2] 庄立[1,2] 童寒波 

机构地区：[1]宁波市卫生防疫站 [2]浙江省余姚市卫生防疫站

出　　处：《中国工业医学杂志》1997年第2期76-78,共3页Chinese Journal of Industrial Medicine

基　　金：宁波市科委科研(攻关)项目基金

摘　　要：为探讨温石棉对人体的脂质过氧化作用机制，对４７名接触温石棉的女工和１５名女性石棉肺病人血清ＭＤＡ、ＳＯＤ、ＧＳＨ－Ｐｘ进行了研究，并分别与１５名无石棉接触女工和接尘女工对照，采用ｔ检验、相关分析。结果可见接尘组女工血清中ＭＤＡ、ＳＯＤ、ＧＳＨ－Ｐｐｘ等显著高于对照组（Ｐ＜０．００１），接尘组与石棉肺病人组血清ＭＤＡ、ＳＯＤ、ＧＳＨ－ｐｘ等各项指标均无显著差别（Ｐ＞０．０５）。提示温石棉可引起接触女工和石棉肺患者的脂质过氧化和抗氧化荫等的变化，表明脂质过氧化在温石棉致病中起着重要作用。ＭＤＡ及抗氧化酶如ＳＯＤ等有望成为早期诊断和动态观察的敏感指标。To investigate the mechanism of lipid peroxidation by which chrysotile fibres exert their effect on human body , plasma level of malonyldialdehyde (MDA) , activities of superoxide dis- mutase (SOD) and glutathione peroxidase (GSH-Px) were determined in 47 female workers exposed to chrysotile fibres , 15 female asbestosis patients and positive and negative control groups , respec- tively. Results showed that the MDA level and SOD and GSH-Px activities among exposed female workers were significantly higher than that of the non-exposed control (P<0. 001) , while , the plas- mic level of MDA and the activities of SOD , GSH-Px of the asbestosis patients were not significant- ly different (P>0.05) from that of the chrysotile-exposed control. The results suggested that there was an involviment of lipid peroxidation and antioxidant mechanisms in the pathogenesis of as- bestosis, and the levels of MDA and antioxidase such as SOD might be the sensitive indices for pre- diction and trending observation of asbestosis .

关 键 词：温石棉 脂质过氧化 超氧化物岐化酶 SOD 

分 类 号：R135.2[医药卫生—劳动卫生]