转化生长因子β_1与高血压肾损害的相关性研究  

Correlation of transforming growth factor-β_1 and hypertensive renal damage.

作　　者：薛浩[1] 崔秋英[2] 李卫菊[1] 刘国树[3] 惠汝太 

机构地区：[1]阜外心血管病医院中德实验室,北京100373 [2]河北省人民医院免疫室 [3]解放军总医院南楼心内科

出　　处：《中国综合临床》2007年第8期676-678,共3页Clinical Medicine of China

摘　　要：目的探讨转化生长因子β_1(TGF-β_1)与高血压肾损害发生发展的关系。方法将95例高血压患者根据其尿蛋白排泄率分为3组:单纯高血压组35例,高血压微量蛋白尿组32例,高血压临床蛋白尿组28例。采用双抗体夹心酶联免疫法(ELISA)检测血清TGF-β_1水平,并与30例正常对照组进行比较。结果高血压各组血清TGF-β_1水平均高于正常对照组(P<0.05),随着尿蛋白排泄率的增加,血清TGF-β_1水平呈上升趋势,组间比较差异有统计学意义(P<0.05);相关分析表明高血压各组血清TGF-β_1水平与尿蛋白排泄率成正相关(r=0.51,P<0.01),而与收缩压、舒张压水平不相关。结论高血压患者循环中TGF-β_1水平明显升高,TGF-β_1参与高血压肾损害的发生发展。Objective To investigate the correlation of transforming growth factor-β1 （ TGF-β1 ） and the development of hypertensive renal damage. Methods 95 patients with hypertension were divided into three groups according to their urinary albumin excretion ： normoalbuminuric hypertensive group （ n = 35 ） , microalbuminuric hypertensives group （ n = 32 ） and proteinuric hypertensives group （ n = 28 ）. Serum TGF-β1 was detected with enzyme linked immune absorption assay （ELISA） ,compared with those in 30 healthy subjects. Results Serum TGF-β1 levels were significantly higher in patients with essential hypertension than those in normoltension controls （ P 〈 0.05 ）. Serum TGF-β1 levels increased significantly with the development of urinary albumin excretion ,with signticant difference among groups （P 〈 0.05 ）. Serum TGF-β1 levels were correlated positively with their urinary albumin excretion （ r = 0.51,P 〈 0.01 ） but not with the extent of systolic and diastolic BP. Condnsion Serum TGF-β1 levels are remarkably increased in hypertensive patients ,which play an important role in the pathogensis and development of hypertensive renal damage.

关 键 词：高血压 转化生长因子Β1 肾损害 

分 类 号：R544.1[医药卫生—心血管疾病]