艾灸对胃粘膜损伤的保护作用及其与一氧化氮的关系  

The Protective Effect of Moxibustion on Gastric Mucosal Damage and the Relation with Nitric Oxide in Rats

作　　者：许冠荪[1] 裴文芬[1] 王月芳[1] 孙勇[1] 朱舜丽[1] 唐照亮[1] 宋小鸽[1] 张道芹[1] 

机构地区：[1]安徽中医学院针灸经络所,合肥230038

出　　处：《针刺研究》1997年第3期175-177,共3页Acupuncture Research

基　　金：国家攀登计划项目!JL-93012

摘　　要：Acute model of gastric mucosal damage induced by perfusion of the 70% ethanol in to stomachwas estab1ished. Gastric mucosal blood flow(GMBF), transmucosal potential difference(PD) and gastric mucosal lesion indices and the contents of nitric oxide (NO) in blood and gastric mucosal were detected. The protective effect of moxibustion(M) on gastric mucosal damage in rats and the relationwith nitric oxide were studied. The results obtained were as follows: 1) M has protective effect on gastric mucosal damage in rats. 2) Both precursor of NO-L-arginine(L-arg) and donor of NO-natrii nitroprussidum(SNP) also has the protective effect on gastric mucosal damage in rats. But NO synthesis inhibltor-NG-nitric-L-arginine(L-NNA) could not have the gastroprotective effect. 3 ) By both pretreatment of L-arg and SNP, the gastroprotective effect of M was increased, but by pretreatment of L-NNAand L-arg, the gastroprotective effect was reversed. However, by pretreatment of I,-NNA, the gastroprotective effect of M was decreased. Conclusion: the protective effect of M on gastric mucosal damagein rats was mediated through activation of L-arg-NOAcute model of gastric mucosal damage induced by perfusion of the 70% ethanol in to stomachwas estab1ished. Gastric mucosal blood flow(GMBF), transmucosal potential difference(PD) and gastric mucosal lesion indices and the contents of nitric oxide (NO) in blood and gastric mucosal were detected. The protective effect of moxibustion(M) on gastric mucosal damage in rats and the relationwith nitric oxide were studied. The results obtained were as follows: 1) M has protective effect on gastric mucosal damage in rats. 2) Both precursor of NO-L-arginine(L-arg) and donor of NO-natrii nitroprussidum(SNP) also has the protective effect on gastric mucosal damage in rats. But NO synthesis inhibltor-NG-nitric-L-arginine(L-NNA) could not have the gastroprotective effect. 3 ) By both pretreatment of L-arg and SNP, the gastroprotective effect of M was increased, but by pretreatment of L-NNAand L-arg, the gastroprotective effect was reversed. However, by pretreatment of I,-NNA, the gastroprotective effect of M was decreased. Conclusion: the protective effect of M on gastric mucosal damagein rats was mediated through activation of L-arg-NO pathway

关 键 词：艾灸 胃粘膜损伤 一氧化氮 保护作用 

分 类 号：R245.8[医药卫生—针灸推拿学]