组胺H2受体在大肠癌组织的表达及其临床意义  

Expression and the effect of histamine-2 receptor on colonrectal carcinoma

作　　者：欧阳志[1] 李汉贤[1] 禹正扬[1] 

机构地区：[1]湖南省南华大学附属第一医院肿瘤外科,衡阳市421001

出　　处：《中国医学文摘（肿瘤学）》2007年第2期176-177,180,共3页Journal of Chinese Medical Abstracts·Oncology

摘　　要：目的：研究组胺H2受体在大肠癌组织中的表达，探讨组胺H2受体在大肠癌各类型之间的差异及其临床意义。方法：采用S-P免疫组织化学方法检测组胺H2受体在大肠癌组织中的表达。选择20例非大肠癌患者正常结肠组织为对照。结果：60例大肠癌组织H2受体阳性表达率为86．667％；而60例大肠癌癌旁组织阳性表达率为11．667％；正常结肠组织H2受体阳性表达率为5．0％。大肠癌H2受体阳性表达率与高、中、低分化组织学分型有关，差异有显著性（P〈0．05）；而与性别、年龄、部位、肿瘤大小、淋巴结转移及TNM分期无明显相关．差异无显著性（P〉0．05）。结论：组胺H2受体在大肠癌组织与癌旁组织及非大肠癌患者正常结肠组织中存在表达差异，H2受体阳性表达率与大肠癌的高、中、低分化组织学分型有关。Objective：To lnvestgate the expression of histamine-2（H2） receptor on colorectal cancer, and determine the difference of expression and the significance of H2 receptor on human colonrectal carcinomas. Methods：Immunohistochemical method was used to detect the expression of H2 receptor on colorectal cancer. Results：The incidence of H2 receptor expression was 86. 667% on 60 human colorectal cancer,11. 667% on 60 human organization by the side of cancer,5.0% on 20 human colorectal tissue. The incidence of H2 receptor expression is connected with microanatomy type, and the difference is notable（P〈0.05）;and not independent of sex,age,location,tumor size,metastasis of lymph node,TNM stages, and the difference is not notable（P〉0.05）. Conclusion：There is positive expression of H2 receptor on colorectal cancer. The expression difference of H2 receptor is exist on colorectal cancer,organization by the side of cancer and human colorectal tissue. The positive incidence of H2 receptor expression is connected with microanatomy type. l

关 键 词：组胺 H2受体 大肠癌 免疫组织化学 

分 类 号：R975.6[医药卫生—药品]