20例男性2型糖尿病患者性激素结合球蛋白和性激素的测定及相关因素分析  

Levels of serum sex hormone binding globulin and sex hormone in 20 male patients with type 2 di-abetes mellitus and analysis of their correlated factors

作　　者：胡蜀红[1] 邓爱群 蔡仕林[1] 张建华[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院内分泌科,武汉430030 [2]湖北省中山医院内分泌科

出　　处：《中国医师进修杂志（内科版）》2007年第7期4-5,8,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 研究男性2型糖尿病患者性激素结合球蛋白（SHBG）和性激素的变化及相关因素分析。方法 检测了20例男性2型糖尿病患者（糖尿病组）和10例糖耐量正常的男性（对照组）血清SHBG、睾酮（T）和雌二醇（E2）浓度。结果SHBG、T和E2浓度在糖尿病组分别为（62.50±27.08）nmol／L、（48.41±9.96）nmol／L和（150.84±96.81）pmol／L，而在对照组分别为（74.16±32.30）nmoL／L、（50.55±12.39）nmol／L和（166.03±121.55）pmol／L，三个指标两组间比较差异均无统计学意义（P〉0.05）。糖尿病组组内相关因素分析发现，SHBG与年龄呈正相关（r=0.54，P〈0.01），与体重指数（BMI）呈负相关（r=-0.46，P〈0.01），并与空腹胰岛素呈负相关（r=-0.48，P〈0.01）。逐步回归分析发现，年龄和BMI对SHBG影响最大。结论2型糖尿病本身对SHBG和性激素浓度无明显影响，而年龄和BMI是其独立影响因素。Objective To study the levels of serum sex hormone binding globulin （SHBG） and sex hormone [ testosterone （T） and estradiol （E2）] in male patients with type 2 diabetes mellitus （T2DM）. Methods The levels of SHBG, T and E2 were measured in 20 male patients with T2DM （T2DM group） and 10 normal people （control group）. Results SHBG, T and E2 levels in T2DM group were （62.50 ±27.08 ） nmol/L, （48.41±9.96） nmol/L and （ 150.84±96.81 ） pmol/L respective-ly, and in control group were （74.16±32.30） nmol/L, （50.55±12.39） nmol/L and （166.03±121.55） pmol/L respectively. There were no significantly difference in T2DM group and control group in levels of SHBG, T and E2. In T2DM group, SHBG was positively correlated with age （ r=0.54, P〈0.01）, negatively correlated with BMI （r=-0.46 ,P 〈0.01）, and negatively correlated with fasting in- sulin levels （r=-0.48 ,P 〈 0.01 ）. Stepwise regression analysis demonstrated that age and BMI were in-dependent correlated factors to SHBG. Conclusion T2DM does not affect the levels of SHBG and sex hormone in male patients with T2DM, but age and BMI are directly influence factors.

关 键 词：2型糖尿病 性激素结合球蛋白 性激素 

分 类 号：R392.1[医药卫生—免疫学]