经氯硝柳胺浸泡后湖北钉螺脑神经节的超微结构变化  

ULTRASTRUCTURAL CHANGES OF CEREBRAL GANGLION OF ONCOMELANIA HUPENSIS AFTER IMMERSION IN NICLOSAMIDE

作　　者：李文桂 黄四喜 徐明星 汪燕鸣 胡来林 高竹琴 程忠跃 王颜 周海林 詹仲伟 唐超[2] 

机构地区：[1]武汉市血吸虫病防治研究所 [2]同济医科大学寄生虫学教研室

出　　处：《中国寄生虫病防治杂志》1997年第1期42-45,共4页Chinese Journal of Parasitic Disease Control

摘　　要：用透射电镜进一步观察了湖北钉螺脑神经节的纤维鞘、神经节胞体区和神经纤维网的超微结构，并且在神经纤维网部位首次发现了两个典型突触。经氯硝柳胺浸泡后，钉螺脑神经节的超微结构发生改变，神经纤维、神经胶质细胞和神经细胞内的线粒体由变性至坏死，神经细胞体内的糖原含量显著减少，神经纤维网也发生变性坏死，这为阐明氯硝柳胺的灭螺机制提供了有用的资料。The ultrastructures of the fibrous sheath, the layer of ganglionic cell bodies and the neuropil of cerebral ganglion of Oncomelania hupensis were observed under transmission electron microscope. Two typical synapses were found in the neuropil for the first time. Ultrastructural changes were found in the cerebral ganglion after the snails were immersed in niclosamide. The mitochondrion of neural fibers, neuroglial cells and neurons showed denatruation and necrosis, and glycogen in neurons was markedly reduced. The neuropil also exhibited denatruation and necrosis. These ultrastructural findings may provide useful information for clarifying the molluscacidal mechanism of Niclosamide.

关 键 词：湖北钉螺 氯硝柳铵 超微结构 钉螺 

分 类 号：R184.38[医药卫生—流行病学]