代谢综合征患者内脏脂肪组织蛋白酪氨酸磷酸酶1B表达增多  

Overexpression of tyrosine protein phosphatase 1B in adipose tissues of newly diagnosed metabolic syndrome patients

作　　者：王淼[1] 邹大进[1] 侯炯[2] 

机构地区：[1]第二军医大学长海医院内分泌科,上海200433 [2]第二军医大学长海医院麻醉科,上海200433

出　　处：《中国糖尿病杂志》2007年第6期321-322,共2页Chinese Journal of Diabetes

摘　　要：目的研究蛋白酪氨酸磷酸酶1B(PTP-1B)在代谢综合征(MS)发病中的作用。方法51例患者分为对照(NC)组、2型糖尿病(T2DM)组和MS组,测定FPG、FIns,Western印迹法测定内脏脂肪组织PTP-1B表达水平。结果与NC组相比,T2DM组和MS组FPG、Ln(HOMA-IR)和PTP-1B表达水平明显升高。与T2DM组相比,MS组腰围和PTP-1B显著升高。校正年龄后PTP-1B与FPG、Ln(HOMA-IR)、腰围(WC)和SBP均呈正相关。结论内脏脂肪组织PTP-1B表达升高与肥胖、糖代谢紊乱等MS危险因素明显相关,可见内脏脂肪组织PTP-1B表达异常与MS发生发展关系密切。Objective To investigate the role of protein tyrosine phosphatase 1B（PTP-1B） in patbogenesis of metabolic syndrome（MS）. Methods Fifty-one patients were divided into 3 groups： type 2 diabetes group（DM）, MS group（MS） and control group（C）. Fasting blood glucose and fasting insulin were determined. Expression of PTP-1B in adipose tissues were determined by Western blot. Results Compared with NC, T2DM and MS groups bad higher FPG, Ln（HOMA-IR） and PTP-1B. Compared with T2DM, waistline and PTP-1B of MS was higher. After controlled for age, TPT- 1B was positively related with waistline, Ln（HOMA-IR）, FPG and systolic pressure. Conclusions Overexpression of PTP-1B in adipose tissues is related to such disorder of glycometabolism and obesity as MS risk factors, which shows PTP-1B participates in pathogenesis of MS.

关 键 词：蛋白酪氨酸磷酸酶1B 代谢综合征 脂肪组织 

分 类 号：R589[医药卫生—内分泌]