紫癜宁胶囊对血小板减少症的实验研究  

Experimental study about Zidianling capsule on thrombocytompenia

作　　者：黄美星[1] 谢振家[1] 刘诗洪 

机构地区：[1]福建卫生职业技术学院新药药理研究中心,福州350001

出　　处：《海峡药学》2007年第6期41-43,共3页Strait Pharmaceutical Journal

摘　　要：目的观察紫癜宁胶囊对血小板减少症的防治作用。方法给小白鼠注射环磷酰胺(CTX)致血小板减少和给豚鼠抗血小板血清诱发免疫性血小板减少(ITP),口服(灌胃)给3个剂量紫癜宁胶囊,观察药效。结果紫癜宁胶囊18g.kg-1、9g.kg-1和4.5g.kg-13个剂量,连续给药15d,均能显著减轻环磷酰胺致小白鼠血小板减少;紫癜宁胶囊10g.kg-1、5g.kg-1和2.5g.kg-13个剂量,连续给药11d,也能显著减轻注射抗血小板血清诱发免疫性豚鼠血小板减少。结论紫癜宁胶囊有防治血小板减少症作用。OBJECTIVE To observe the effects of Zhdianling capsule on animal model of thrombocytompenia. METHODS Thrombocytompenia model of mice was made by injecting cytotoxic （ CTX 100 mg/（ kg·d）, ip） for three days and thrombocytompenia model of quinea pigs（ITP） was made by injecting intraperitoneal anti-platelet serum. RESULTS Zidianling capsule increased the peripheral platelet, showing a significant difference from that of control group（P 〈 0.01 ）. CONCLUSION Zidianling has a significantly therapeutic effect on thrombocytompenia model induced by CTX in mice and by anti-platelet serum in quinea pigs.

关 键 词：紫癜宁胶囊 血小板减少少症 环磷酰胺胺(CTX) 免疫性血小板减少(ITP) 小白鼠 豚鼠 

分 类 号：R969[医药卫生—药理学]