粉防己碱对鼠脑缺血的保护作用  

Protective effect of tetrandrine on acute cerebral ischemia in mice and rats

作　　者：祝晓光[1] 顾丽英[1] 陈桂英[1] 田宏 金其泉 

机构地区：[1]蚌埠医学院应用药物研究所

出　　处：《中国药理学通报》1997年第2期148-150,共3页Chinese Pharmacological Bulletin

摘　　要：目的：研究粉防己碱（Ｔｅｔ）对鼠脑缺血的保护作用。方法：采用小鼠断颅和结扎大鼠双侧颈总动脉并人工降压至６．７ｋＰａ复制急性脑缺血模型。结果：Ｔｅｔ（１５ｍｇ·ｋｇ－１）可明显延长小鼠断颅后的喘息时间，能明显改善大鼠的脑电活动，可降低脑钙、水含量，降低脑静脉血中乳酸脱氢酶和磷酸肌酸激酶含量。结论：提示Ｔｅｔ对脑缺血有保护作用。Objective\ To investigate protective effect of tetrandrine (Tet) on acute cerebral ischemia in mice and rats. Methods\ Acute incomplete cerebral ischemia was induced successfully by cutting heads in mice and bilateral common carotid arteries were ligated with blood pressure (MABP) reaching 6 7 kPa (hemorrhagic hypotension) in rats. Results\ Tet (15 mg·kg -1 ) significantly prolaged asthmatic time on cutting heads in mice, and improved the brain electrical activity and reduced content of Ca 2+ /water in rats. It reduced concentration of lactale dehydrogenase (LDH) and creatine phasphokinase (CPK) release in venous blood. Conclusions\ The results indicate that Tet has the protective effect on acute cerebral ischemia injury.

关 键 词：粉防己碱 脑缺血 脑电图 乳酸脱酸酶 激酶 

分 类 号：R282.710.5[医药卫生—中药学] R285.5[医药卫生—中医学]